*Inouye Eye Hospital, Chiyoda-ku †Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan.
J Glaucoma. 2013 Oct-Nov;22(8):626-31. doi: 10.1097/IJG.0b013e31824d8d7c.
Upper eyelid sulcus deepening has recently been reported as an adverse effect of prostaglandin (PG) eye drop use. However, no data are available regarding the frequency of upper eyelid sulcus deepening caused by different types of PG eye drops. We used 5 types of PG eye drops in Japanese subjects and examined the frequency of appearance of upper eyelid sulcus deepening in these subjects.
The study included 250 patients (250 eyes) diagnosed with primary open-angle glaucoma or ocular hypertension. Five healthy patients were included as controls. One eye of each patient was treated with one of the following PG eye drops for >3 months: latanoprost, travoprost, tafluprost, bimatoprost, and isopropyl unoprostone. A single-lens reflex camera was used to photograph the open eyelids. Three ophthalmologists independently judged the appearance of the deepened upper eyelid sulcus in the photographs of the 250 patients and 5 controls by comparing the right and left eyes. A subjective self-reported symptom questionnaire was also administered.
Upper eyelid sulcus deepening was objectively (photograph) and subjectively (questionnaire) noted in 24.0% and 12.0%, 50.0% and 24.0%, 18.0% and 10.0%, 60.0% and 40.0%, and 8.0% and 10.0% of the patients in the latanoprost, travoprost, tafluprost, bimatoprost, and unoprostone groups, respectively. It occurred more frequently (objectively and subjectively) in the bimatoprost group than in the latanoprost, the tafluprost, and the unoprostone groups (P<0.001).
Upper eyelid sulcus deepening frequently occurred with bimatoprost usage, and this effect should be sufficiently elucidated before starting bimatoprost treatment.
最近有报道称，前列腺素（PG）滴眼剂的使用会导致上睑沟变深，这是一种不良反应。然而，目前尚无关于不同类型 PG 滴眼剂引起的上睑沟变深频率的数据。我们在日本受试者中使用了 5 种 PG 滴眼剂，并检查了这些受试者出现上睑沟变深的频率。
该研究纳入了 250 例（250 只眼）被诊断为原发性开角型青光眼或高眼压症的患者。纳入 5 例健康受试者作为对照。将每位患者的每只眼分别使用以下 5 种 PG 滴眼剂中的 1 种治疗>3 个月：拉坦前列素、曲伏前列素、他氟前列素、贝美前列素和异丙基乌诺前列酮。使用单镜头反射相机拍摄开睑照片。3 位眼科医生通过比较左右眼，独立判断 250 例患者和 5 例对照者照片中是否出现上睑沟变深。还对患者进行了主观的自我报告症状问卷调查。
24.0%和 12.0%、50.0%和 24.0%、18.0%和 10.0%、60.0%和 40.0%、8.0%和 10.0%的患者在拉坦前列素、曲伏前列素、他氟前列素、贝美前列素和乌诺前列酮组中分别出现了上睑沟变深（客观和主观）。与拉坦前列素、他氟前列素和乌诺前列酮组相比，贝美前列素组中更频繁地出现上睑沟变深（客观和主观）（P<0.001）。
与使用拉坦前列素、他氟前列素和乌诺前列酮相比，贝美前列素更常引起上睑沟变深，在开始使用贝美前列素治疗之前，应充分阐明其这一作用。
