Department of Ophthalmology, Gulhane Military Academy of Medicine, Ankara, Turkey.
Clin Exp Ophthalmol. 2014 Mar;42(2):126-31. doi: 10.1111/ceo.12163. Epub 2013 Aug 4.
To investigate the frequency of prostaglandin-associated periorbitopathy among bimatoprost, latanoprost and travoprost users.
Retrospective observational case series.
The study group included 105 patients who were using one of the drugs in one eye for more than 1 month, and the other eye was used as a control.
The frequency of prostaglandin-associated periorbitopathy.
Special care was taken to detect five prostaglandin-associated periorbitopathy findings. Hertel exophthalmometry measurements and colour pictures of the periocular area were taken.
Statistically significant differences were found among the groups regarding the presence of all prostaglandin-associated periorbitopathy findings (P < 0.05). Periorbital fat loss was the most frequent and was observed in nearly all prostaglandin-associated periorbitopathy patients except those who were relatively young. The overall frequency of prostaglandin-associated periorbito pathy was 93.3% in the bimatoprost group, 41.4% in the latanoprost group and 70% in the travoprost group. The frequency of deepening of the upper lid sulcus was 80% in the bimatoprost group, 15.7% in the latanoprost group and 45% in the travoprost group. The frequency of milder changes (the presence of either only periorbital fat loss or dermatochalasis involution or the presence of both) was higher in the latanoprost group (62%) than in the travoprost (35.7%) and bimatoprost (7.1%) groups.
Prostaglandin-associated periorbitopathy is as common as other adverse effects when careful examinations are performed and is more frequent and more severe in bimatoprost users. The loss of the periorbital fat pad is the first sign to occur during the evolution of prostaglandin-associated periorbitopathy, especially in older patients.
研究比马前列素、拉坦前列素和曲伏前列素使用者中前列腺素相关眶周病的发生频率。
回顾性观察性病例系列。
研究组纳入了 105 名患者，他们在一只眼中使用其中一种药物超过 1 个月，另一只眼作为对照。
前列腺素相关眶周病的发生频率。
特别注意检测五种前列腺素相关眶周病发现。进行 Hertel 突眼度测量和眶周区域彩色照片拍摄。
各组之间所有前列腺素相关眶周病发现的存在存在统计学显著差异（P<0.05）。眶周脂肪丧失是最常见的，除了相对年轻的患者外，几乎所有前列腺素相关眶周病患者都有眶周脂肪丧失。比马前列素组前列腺素相关眶周病的总发生率为 93.3%，拉坦前列素组为 41.4%，曲伏前列素组为 70%。比马前列素组上睑沟加深的发生率为 80%，拉坦前列素组为 15.7%，曲伏前列素组为 45%。轻度变化（仅存在眶周脂肪丧失或皮肤松弛萎缩或两者均存在）的发生率在拉坦前列素组（62%）高于曲伏前列素组（35.7%）和比马前列素组（7.1%）。
当进行仔细检查时，前列腺素相关眶周病与其他不良反应一样常见，并且在比马前列素使用者中更频繁和更严重。眶周脂肪垫的丧失是前列腺素相关眶周病发生过程中的第一个迹象，尤其是在老年患者中。
