Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Org Biomol Chem. 2012 Oct 21;10(39):7949-51. doi: 10.1039/c2ob26346g. Epub 2012 Aug 30.
β-Lithiooxyphosphonium ylides, made in situ from an aldehyde and methylenetriphenylphosphorane, react with a second aldehyde to form E-allylic alcohols. α-Branching and α,β-unsaturation in the second aldehyde, together with the lack of further substitution on the phosphorane carbon play important roles in selectivity. A range of these aldehydes, in addition to aromatic aldehydes as the second aldehyde also provided synthetically useful access to E-allylic alcohols.
β-锂氧磷叶立德由醛和亚甲基三苯膦原位反应制得，与第二个醛反应生成 E-烯丙醇。第二个醛中的α-支链和α,β-不饱和性，以及磷叶立德碳上缺乏进一步取代，对选择性起着重要作用。除了芳香醛作为第二个醛外，这些醛中的一系列化合物也为 E-烯丙醇的合成提供了有用的途径。
