Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu, People's Republic of China.
Cell Mol Life Sci. 2012 Nov;69(21):3601-12. doi: 10.1007/s00018-012-1129-8. Epub 2012 Aug 31.
As master gene regulators, microRNAs are involved in diverse cellular pathways. It is well known that microRNAs are often dysregulated in many types of cancer and other human diseases. In cancer, microRNAs may function as oncogenes or tumor suppressors. Interestingly, recent evidence suggests that microRNA-mediated gene regulation interconnects with the Akt pathway, forming an Akt-microRNA regulatory network. MicroRNAs and Akt in this network work together to exert their cellular functions. Thus, a better understanding of this Akt-microRNA regulatory network is critical to successful targeting of the PI3K/Akt pathway for cancer therapy. We review recent advances in the understanding of how microRNAs affect Akt activity as well as how microRNAs are regulated through the Akt pathway. We also briefly discuss the clinical implication of gene regulation mediated through Akt-associated microRNAs.
作为主调控基因，microRNAs 参与了多种细胞途径。众所周知，microRNAs 在许多类型的癌症和其他人类疾病中经常失调。在癌症中，microRNAs 可能作为癌基因或肿瘤抑制因子发挥作用。有趣的是，最近的证据表明，microRNA 介导的基因调控与 Akt 途径相互连接，形成 Akt-microRNA 调控网络。该网络中的 microRNAs 和 Akt 共同发挥其细胞功能。因此，更好地理解这种 Akt-microRNA 调控网络对于成功靶向癌症治疗的 PI3K/Akt 途径至关重要。我们综述了 microRNAs 如何影响 Akt 活性以及 microRNAs 如何通过 Akt 途径进行调控的最新进展。我们还简要讨论了通过 Akt 相关 microRNAs 介导的基因调控的临床意义。
