Rasmi Yousef, Mohamed Yara Ahmed, Alipour Shahriar, Ahmed Salma, Abdelmajed Samar Samir
Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Cellular and Molecular Research Center, Cellular and Molecular Research Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
J Diabetes Metab Disord. 2023 Oct 11;23(1):39-47. doi: 10.1007/s40200-023-01317-y. eCollection 2024 Jun.
Diabetes mellitus [DM], is a multifaceted metabolic disease, which has become a worldwide threat to human wellness. Over the past decades, an enormous amount of attention has been devoted to understanding how microRNAs [miRNAs], a class of small non-coding RNA regulators of gene expression at the post-transcriptional level, are tied to DM pathology. It has been demonstrated that miRNAs control insulin synthesis, secretion, and activity. This review aims to provide an evaluation of the use of miR-143 and miR-145 as biomarkers for the diagnosis and prognosis of diabetes.
The use of miR-143 and miR-145 as biomarkers for the diagnosis and prognosis of diabetes has been studied, and research that examined this link was sought after in the literature. In addition, we will discuss the cellular and molecular pathways of insulin secretion regulation by miR-143/145 expression and finally their role in diabetes.
In the current review, we emphasize recent findings on the miR-143/145 expression profiles as novel DM biomarkers in clinical studies and animal models and highlight recent discoveries on the complex regulatory effect and functional role of miR-143/145 expression in DM.
A novel clinical treatment that alters the expression and activity of miR-143/miR-145 may be able to return cells to their natural state of glucose homeostasis, demonstrating the value of using comprehensive miRNA profiles to predict the beginning of diabetes.
The online version contains supplementary material available at 10.1007/s40200-023-01317-y.
糖尿病（DM）是一种多方面的代谢性疾病，已成为对人类健康的全球性威胁。在过去几十年中，人们投入了大量精力来了解微小RNA（miRNA），这是一类在转录后水平调节基因表达的小型非编码RNA调节因子，与糖尿病病理之间的关系。已经证明，miRNA控制胰岛素的合成、分泌和活性。本综述旨在评估miR-143和miR-145作为糖尿病诊断和预后生物标志物的应用。
研究了miR-143和miR-145作为糖尿病诊断和预后生物标志物的应用，并在文献中寻找研究这一联系的研究。此外，我们将讨论miR-143/145表达调节胰岛素分泌的细胞和分子途径，以及它们最终在糖尿病中的作用。
在本综述中，我们强调了临床研究和动物模型中关于miR-143/145表达谱作为新型糖尿病生物标志物的最新发现，并突出了miR-143/145表达在糖尿病中的复杂调节作用和功能的最新发现。
一种改变miR-143/miR-145表达和活性的新型临床治疗方法可能能够使细胞恢复到葡萄糖稳态的自然状态，这证明了使用综合miRNA谱预测糖尿病发病的价值。
在线版本包含可在10.1007/s40200-023-01317-y获取的补充材料。
