Comunoglu C, Comunoglu N, Eren B, Tanrlöver O, Türkmen N, Gündogmuş U N, Eren F
Department of Pathology, Near East University Faculty of Medicine, Nicosia, North Cyprus.
Folia Morphol (Warsz). 2012 Aug;71(3):178-82.
Histopathological features of the cardiac conducting system (CCS) in the Turkish population have not been investigated previously.
We examined CCS of 202 autopsy heart specimens dissected between the years 2004 and 2005 in Bursa Forensic Medicine Institution. Of the 202 cases from all age groups, 154 were males and 48 were females.
In our cases, an increase in fibrous and adipose tissue concordant with age, indicating an age-related nature, were detected. Fibrous and fatty tissue infiltration appeared at the age of 35. Fatty infiltration started between the ages 20 and 34 years at the sinoatrial node (SAN). There was no relationship between obesity and fatty tissue infiltration in SAN and atrioventricular node (AVN). In 4 cases calcification and in 19 cases inflammation was observed. Amyloid accumulation was not present. In 7 cases myocardial infarction not involving CCS was seen. In 1 case fibroelastoma was detected.
In the Turkish population age-related fibrosis and fatty infiltration in CCS appeared at the age of 35 years and increased with age. Fatty infiltration in the SAN started at a younger age than that reported in the literature. In cases where the cause of death could not be determined, we could not detect lethal pathological features. However, we think that examination of the CCS will improve the quality of autopsy diagnosis.
此前尚未对土耳其人群心脏传导系统（CCS）的组织病理学特征进行过研究。
我们检查了2004年至2005年间在布尔萨法医学机构解剖的202例尸检心脏标本的CCS。在所有年龄组的202例病例中，男性154例，女性48例。
在我们的病例中，检测到纤维组织和脂肪组织随年龄增加，表明具有年龄相关性。纤维组织和脂肪组织浸润在35岁时出现。脂肪浸润在20至34岁之间始于窦房结（SAN）。肥胖与SAN和房室结（AVN）的脂肪组织浸润之间无相关性。观察到4例钙化和19例炎症。未发现淀粉样物质积聚。7例可见未累及CCS的心肌梗死。1例检测到纤维弹性瘤。
在土耳其人群中，CCS中与年龄相关的纤维化和脂肪浸润在35岁时出现并随年龄增加。SAN中的脂肪浸润开始年龄比文献报道的要早。在死因无法确定的病例中，我们未检测到致命的病理特征。然而，我们认为对CCS的检查将提高尸检诊断的质量。
