Luo Bo-tao, Jiang Han-guo, Zhao Ying-hai, Chen Xiao-yi
Department of Pathology of Guangdong Medical College, Zhanjiang 524023, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2010 Apr;38(4):350-3.
To explore the risk factors related to the formation of myocardial fatty infiltration and possible pathological consequences.
The macroscopic and microscopic findings in 117 autopsy cases with myocardial fatty infiltration were examined during October, 2001 to June, 2009.
There was a significant positive correlation between the macroscopic grading of subepicardial adipose tissue and the microscopic myocardial fatty infiltrative degree(r(s) = 0.57, P < 0.01) but there was no correlations between the myocardial fatty infiltrative degree and age as well as coronary arteriosclerosis (all P > 0.05). The percent of myocardial atrophy was 39.32% (46/117), and the rate of myocardial atrophy in mild myocardial fatty infiltration group (13/63, 20.63%) was significantly lower than that in moderate myocardial fatty infiltration group (22/39, 34.92%; chi(2) = 12.14, P < 0.01) and in severe myocardial fatty infiltration group (11/15, 73.33%; chi(2) = 13.42, P < 0.01). There were 28 sudden cardiac deaths among the 117 cases including 6 deaths due to myocardial fatty infiltration.
Myocardial fatty infiltration is often associated with myocardial atrophy, even with sudden cardiac death but is not an accompanying pathologic changes of aging and coronary arteriosclerosis.
探讨与心肌脂肪浸润形成相关的危险因素及可能的病理后果。
对2001年10月至2009年6月间117例心肌脂肪浸润尸检病例的大体及显微镜检查结果进行分析。
心外膜下脂肪组织大体分级与心肌脂肪浸润显微镜下程度呈显著正相关（r(s)=0.57，P<0.01），但心肌脂肪浸润程度与年龄及冠状动脉硬化均无相关性（均P>0.05）。心肌萎缩发生率为39.32%（46/117），轻度心肌脂肪浸润组心肌萎缩率（13/63，20.63%）显著低于中度心肌脂肪浸润组（22/39，34.92%；χ(2)=12.14，P<0.01）及重度心肌脂肪浸润组（11/15，73.33%；χ(2)=13.42，P<0.01）。117例中有28例心源性猝死，其中6例死于心肌脂肪浸润。
心肌脂肪浸润常伴有心肌萎缩，甚至可导致心源性猝死，但并非衰老及冠状动脉硬化的伴随病理改变。
