Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan,
Int J Clin Oncol. 2013 Oct;18(5):824-8. doi: 10.1007/s10147-012-0469-6. Epub 2012 Aug 31.
The prevalence of oropharyngeal carcinoma is rising in western Europe and the United States, where there appears to be a strong association between human papillomavirus (HPV) and oropharyngeal squamous cell carcinoma (OPSCC). However, such a correlation has not yet been fully evaluated in Japan.
We performed a retrospective analysis of the association between tumour HPV status and the demographic and clinicopathological parameters of 71 patients with OPSCC at Hokkaido University Hospital, Japan, between 1998 and 2009. The parameters included age, gender, survival, tumour subsite, tumour-node-metastasis (TNM) stage, smoking history, second primary tumour status, recurrence/residual disease at the primary site, and overall survival. HPV status was established by multiplex polymerase chain reaction (PCR) analysis.
Of the 71 oropharyngeal cancers, 20 were positive for HPV-16, two for HPV-18, and one for HPV-58. Kaplan-Meier survival analysis showed improved overall survival rates in patients with HPV-positive tumours (p = 0.0038) compared with HPV-negative tumours. Of the 45 patients who received chemoradiotherapy, HPV-positive patients experienced better overall survival than HPV-negative patients (p = 0.0032). In a multivariate analysis, the survival benefit of HPV-positive patients was independent of age and T and N classification.
HPV status is a significantly favourable prognostic factor in oropharyngeal cancer and could be used as a marker to optimize the treatment of patients with this type of cancer in Japan.
在西欧和美国，口咽癌的发病率正在上升，人乳头瘤病毒（HPV）与口咽鳞状细胞癌（OPSCC）之间似乎存在很强的关联。然而，这种相关性在日本尚未得到充分评估。
我们对日本北海道大学医院 1998 年至 2009 年间收治的 71 例 OPSCC 患者的肿瘤 HPV 状态与人口统计学和临床病理参数之间的关系进行了回顾性分析。这些参数包括年龄、性别、生存、肿瘤部位、肿瘤-淋巴结-转移（TNM）分期、吸烟史、第二原发肿瘤状态、原发部位的复发/残留疾病以及总生存情况。HPV 状态通过多重聚合酶链反应（PCR）分析确定。
在 71 例口咽癌中，20 例 HPV-16 阳性，2 例 HPV-18 阳性，1 例 HPV-58 阳性。Kaplan-Meier 生存分析显示，HPV 阳性肿瘤患者的总生存率明显高于 HPV 阴性肿瘤患者（p = 0.0038）。在接受放化疗的 45 例患者中，HPV 阳性患者的总生存率优于 HPV 阴性患者（p = 0.0032）。在多变量分析中，HPV 阳性患者的生存获益独立于年龄和 T、N 分类。
HPV 状态是口咽癌一个显著有利的预后因素，可作为优化日本此类癌症患者治疗的标志物。
