编码小泛素样修饰蛋白 4（SUMO4）的基因 M55V 多态性与 1 型（和 2 型）糖尿病易感性相关。

Polymorphism M55V in gene encoding small ubiquitin-like modifier 4 (SUMO4) protein associates with susceptibility to type 1 (and type 2) diabetes.

机构信息

Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

出版信息

Diabetes Metab Res Rev. 2012 Nov;28(8):679-87. doi: 10.1002/dmrr.2335.

DOI:10.1002/dmrr.2335

PMID:22936652

Abstract

BACKGROUND

The association between small ubiquitin-like modifier 4 (SUMO4) gene polymorphism and type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM) has been investigated in several studies. We conducted a meta-analysis to evaluate the association of SUMO4 gene polymorphism with T1DM and T2DM susceptibility.

METHODS

A meta-analysis was performed on the published studies before August 2011. The association of SUMO4 M55V polymorphism with T1DM and T2DM was evaluated. Meta-analysis was performed for genotypes AA versus GG, AA versus AG, AA versus AG + GG and A allele versus G allele in a fixed/random effect model. The combined odds ratio (OR) with 95% confidence interval (95% CI) was calculated to estimate the strength of the association.

RESULTS

Sixteen case-control studies including 9190 cases and 10 456 healthy controls were included. T1DM patients were divided into Asian and Caucasian subgroup. We detected a significant association of SUMO4 M55V polymorphism with T1DM in Asian population (A versus G: OR = 0.79, 95%CI = 0.72-0.86, p = 0.000) and a significant association of SUMO4 M55V polymorphism with T1DM in Caucasian population (A versus G: OR = 0.84, 95%CI = 0.73-0.97, p = 0.007). Included T2DM patients were all Asian. Meanwhile, a significant association of SUMO4 M55V polymorphism with T2DM was also found (A versus G: OR = 0.86, 95%CI = 0.79-0.94, p = 0.001).

CONCLUSIONS

Our study demonstrates significant associations of SUMO4 M55V polymorphism with T1DM in Asian and Caucasian population and with T2DM in Asian population.

摘要

背景

小泛素样修饰物 4（SUMO4）基因多态性与 1 型糖尿病（T1DM）或 2 型糖尿病（T2DM）的关联已在多项研究中进行了探讨。我们进行了一项荟萃分析，以评估 SUMO4 基因多态性与 T1DM 和 T2DM 易感性的关联。

方法

对截至 2011 年 8 月前发表的研究进行了荟萃分析。评估了 SUMO4 M55V 多态性与 T1DM 和 T2DM 的相关性。采用固定/随机效应模型，对 AA 基因型与 GG 基因型、AA 基因型与 AG 基因型、AA 基因型与 AG+GG 基因型以及 A 等位基因与 G 等位基因进行了荟萃分析。计算合并优势比（OR）及其 95%置信区间（95%CI）来评估关联的强度。

结果

纳入了包括 9190 例病例和 10456 例健康对照的 16 项病例对照研究。将 T1DM 患者分为亚洲人和高加索人亚组。我们发现 SUMO4 M55V 多态性与亚洲人群 T1DM 显著相关（A 对 G：OR=0.79，95%CI=0.72-0.86，p=0.000），SUMO4 M55V 多态性与高加索人群 T1DM 显著相关（A 对 G：OR=0.84，95%CI=0.73-0.97，p=0.007）。纳入的 T2DM 患者均为亚洲人。同时，还发现 SUMO4 M55V 多态性与 T2DM 显著相关（A 对 G：OR=0.86，95%CI=0.79-0.94，p=0.001）。