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基因M55V多态性与2型糖尿病：一项纳入6823名受试者的荟萃分析。

Gene M55V Polymorphism and Type 2 Diabetes Mellitus: A Meta-analysis Including 6,823 Subjects.

作者信息

Li Yan-Yan, Wang Hui, Yang Xin-Xing, Geng Hong-Yu, Gong Ge, Kim Hyun Jun, Zhou Yan-Hong, Wu Jing-Jing

机构信息

Department of Gerontology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Institute of Clinical Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

出版信息

Front Endocrinol (Lausanne). 2017 Nov 2;8:303. doi: 10.3389/fendo.2017.00303. eCollection 2017.

DOI:10.3389/fendo.2017.00303
PMID:29163370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5673665/
Abstract

BACKGROUND

Many studies suggest that the M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter.

OBJECTIVE AND METHODS

A meta-analysis consisting of 6,823 subjects from 10 studies was conducted to elucidate relationship between the M55V gene polymorphism and T2DM. Depending on the heterogeneity of the data, either a fixed or random-effects model would be used to assess the combined odds ratio (ORs) and their corresponding 95% confidence interval (CI).

RESULTS

gene M55V polymorphism was significantly associated with T2DM in the whole population under allelic (OR: 1.18, 95% CI: 1.10-1.28,  = 1.63 × 10), recessive (OR: 1.59, 95% CI: 1.14-2.23,  = 0.006), dominant (OR: 0.815, 95% CI: 0.737-0.901,  = 6.89 × 10), homozygous (OR: 1.415, 95% CI: 1.170-1.710,  = 0.0003), heterozygous (OR: 1.191, 95% CI: 1.072-1.323,  = 0.001), and additive genetic models (OR: 1.184, 95% CI: 1.097-1.279,  = 1.63 × 10). In our subgroup analysis, a significant association was found again in the Chinese population, but not in Japanese or Iranian population.

CONCLUSION

gene M55V polymorphism may correlate with increased T2DM risk. Chinese carriers of the V allele of the gene M55V polymorphism may be predisposed to developing T2DM.

摘要

背景

许多研究表明，M55V基因多态性（rs237025）可能与2型糖尿病（T2DM）风险增加有关。然而，由于其他相互矛盾的结果，在这个问题上缺乏明确的共识。

目的与方法

对来自10项研究的6823名受试者进行荟萃分析，以阐明M55V基因多态性与T2DM之间的关系。根据数据的异质性，将使用固定效应模型或随机效应模型来评估合并比值比（OR）及其相应的95%置信区间（CI）。

结果

在整个总体中，M55V基因多态性在等位基因（OR：1.18，95%CI：1.10 - 1.28，P = 1.63×10）、隐性（OR：1.59，95%CI：1.14 - 2.23，P = 0.006）、显性（OR：0.815，95%CI：0.737 - 0.901，P = 6.89×10）、纯合子（OR：1.415，95%CI：1.170 - 1.710，P = 0.0003）、杂合子（OR：1.191，95%CI：1.072 - 1.323，P = 0.001）以及加性遗传模型（OR：1.184，95%CI：1.097 - 1.279，P = 1.63×10）下均与T2DM显著相关。在我们的亚组分析中，在中国人群中再次发现显著关联，但在日本或伊朗人群中未发现。

结论

M55V基因多态性可能与T2DM风险增加相关。M55V基因多态性V等位基因的中国携带者可能易患T2DM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/c208d47ac122/fendo-08-00303-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/4adc4e71c12f/fendo-08-00303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/e44e1ba801c6/fendo-08-00303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/0b58f662f9c6/fendo-08-00303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/3abe73e97566/fendo-08-00303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/8e85ae78f430/fendo-08-00303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/69d61f8f9ee3/fendo-08-00303-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/108d2b36d0c8/fendo-08-00303-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/587ee3dd032a/fendo-08-00303-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/c208d47ac122/fendo-08-00303-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/4adc4e71c12f/fendo-08-00303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/e44e1ba801c6/fendo-08-00303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/0b58f662f9c6/fendo-08-00303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/3abe73e97566/fendo-08-00303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/8e85ae78f430/fendo-08-00303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/69d61f8f9ee3/fendo-08-00303-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/108d2b36d0c8/fendo-08-00303-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/587ee3dd032a/fendo-08-00303-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4218/5673665/c208d47ac122/fendo-08-00303-g009.jpg

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