Gene M55V Polymorphism and Type 2 Diabetes Mellitus: A Meta-analysis Including 6,823 Subjects.

BACKGROUND

Many studies suggest that the M55V gene polymorphism (rs237025) may be associated with an increased risk of type 2 diabetes mellitus (T2DM). However, due to other conflicting results, a clear consensus is lacking in the matter.

OBJECTIVE AND METHODS

A meta-analysis consisting of 6,823 subjects from 10 studies was conducted to elucidate relationship between the M55V gene polymorphism and T2DM. Depending on the heterogeneity of the data, either a fixed or random-effects model would be used to assess the combined odds ratio (ORs) and their corresponding 95% confidence interval (CI).

RESULTS

gene M55V polymorphism was significantly associated with T2DM in the whole population under allelic (OR: 1.18, 95% CI: 1.10-1.28,  = 1.63 × 10), recessive (OR: 1.59, 95% CI: 1.14-2.23,  = 0.006), dominant (OR: 0.815, 95% CI: 0.737-0.901,  = 6.89 × 10), homozygous (OR: 1.415, 95% CI: 1.170-1.710,  = 0.0003), heterozygous (OR: 1.191, 95% CI: 1.072-1.323,  = 0.001), and additive genetic models (OR: 1.184, 95% CI: 1.097-1.279,  = 1.63 × 10). In our subgroup analysis, a significant association was found again in the Chinese population, but not in Japanese or Iranian population.

CONCLUSION

gene M55V polymorphism may correlate with increased T2DM risk. Chinese carriers of the V allele of the gene M55V polymorphism may be predisposed to developing T2DM.