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糖尿病β细胞衰竭：1 型和 2 型糖尿病共有的常见易感性和机制。

β-Cell failure in diabetes: Common susceptibility and mechanisms shared between type 1 and type 2 diabetes.

机构信息

Department of Endocrinology, Metabolism and Diabetes, Faculty of Medicine, Kindai University, Osaka-sayama, Osaka, Japan.

出版信息

J Diabetes Investig. 2021 Sep;12(9):1526-1539. doi: 10.1111/jdi.13576. Epub 2021 Jun 16.

DOI:10.1111/jdi.13576
PMID:33993642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8409822/
Abstract

Diabetes mellitus is etiologically classified into type 1, type 2 and other types of diabetes. Despite distinct etiologies and pathogenesis of these subtypes, many studies have suggested the presence of shared susceptibilities and underlying mechanisms in β-cell failure among different types of diabetes. Understanding these susceptibilities and mechanisms can help in the development of therapeutic strategies regardless of the diabetes subtype. In this review, we discuss recent evidence indicating the shared genetic susceptibilities and common molecular mechanisms between type 1, type 2 and other types of diabetes, and highlight the future prospects as well.

摘要

糖尿病在病因学上分为 1 型、2 型和其他类型的糖尿病。尽管这些亚型的病因和发病机制不同，但许多研究表明，不同类型的糖尿病中β细胞衰竭存在共同的易感性和潜在机制。了解这些易感性和机制有助于制定治疗策略，而与糖尿病亚型无关。在这篇综述中，我们讨论了最近的证据，表明 1 型、2 型和其他类型的糖尿病之间存在共同的遗传易感性和共同的分子机制，并强调了未来的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09df/8409822/326e57f1738d/JDI-12-1526-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09df/8409822/2e7a0e9811c7/JDI-12-1526-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09df/8409822/9d9ac75345c8/JDI-12-1526-g005.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09df/8409822/2e7a0e9811c7/JDI-12-1526-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09df/8409822/06dbfc0b61c1/JDI-12-1526-g007.jpg
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The Role of β Cell Stress and Neo-Epitopes in the Immunopathology of Type 1 Diabetes.β 细胞应激与新抗原在 1 型糖尿病免疫病理中的作用。
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Glucokinase Inactivation Paradoxically Ameliorates Glucose Intolerance by Increasing β-Cell Mass in Mice.
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bioRxiv. 2025 May 15:2025.05.11.653323. doi: 10.1101/2025.05.11.653323.
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