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可变前体mRNA剪接调控在神经元发育和功能中的新作用

Emerging Roles of Alternative Pre-mRNA Splicing Regulation in Neuronal Development and Function.

作者信息

Norris Adam D, Calarco John A

机构信息

FAS Center for Systems Biology, Harvard University Cambridge, MA, USA.

出版信息

Front Neurosci. 2012 Aug 21;6:122. doi: 10.3389/fnins.2012.00122. eCollection 2012.

DOI:10.3389/fnins.2012.00122
PMID:22936897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3424503/
Abstract

Alternative pre-mRNA splicing has the potential to greatly diversify the repertoire of transcripts in multicellular organisms. Increasing evidence suggests that this expansive layer of gene regulation plays a particularly important role in the development and function of the nervous system, one of the most complex organ systems found in nature. In this review, we highlight recent studies that continue to emphasize the influence and contribution of alternative splicing regulation to various aspects of neuronal development in addition to its role in the mature nervous system.

摘要

可变前体mRNA剪接有潜力极大地增加多细胞生物中转录本的种类。越来越多的证据表明，这一广泛的基因调控层面在神经系统的发育和功能中发挥着特别重要的作用，神经系统是自然界中最复杂的器官系统之一。在这篇综述中，我们重点介绍了近期的研究，这些研究除了强调可变剪接调控在成熟神经系统中的作用外，还继续强调其对神经元发育各个方面的影响和贡献。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58bc/3424503/eedebed92e6c/fnins-06-00122-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58bc/3424503/8e57261fab05/fnins-06-00122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58bc/3424503/eedebed92e6c/fnins-06-00122-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58bc/3424503/8e57261fab05/fnins-06-00122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58bc/3424503/eedebed92e6c/fnins-06-00122-g002.jpg

相似文献

[1]
Emerging Roles of Alternative Pre-mRNA Splicing Regulation in Neuronal Development and Function.

Front Neurosci. 2012-8-21

[2]
Neuronal regulation of alternative pre-mRNA splicing.

Nat Rev Neurosci. 2007-11

[3]
Regulation of Neuronal Differentiation, Function, and Plasticity by Alternative Splicing.

Annu Rev Cell Dev Biol. 2018-7-20

[4]
Aberrant regulation of alternative pre-mRNA splicing in hepatocellular carcinoma.

Crit Rev Eukaryot Gene Expr. 2014

[5]
Regulation of gene expression in mammalian nervous system through alternative pre-mRNA splicing coupled with RNA quality control mechanisms.

Mol Cell Neurosci. 2013-1-26

[6]
Genome-wide analysis of alternative pre-mRNA splicing.

J Biol Chem. 2008-1-18

[7]
Spatio-temporal regulations and functions of neuronal alternative RNA splicing in developing and adult brains.

Neurosci Res. 2016-8

[8]
Global detection and identification of developmental stage specific transcripts in mouse brain using subtractive cross-screening algorithm.

Genomics. 2013-5-12

[9]
Alternative splicing programming of axon formation.

Wiley Interdiscip Rev RNA. 2020-7

[10]
[Perspectives of RNA interference application in the therapy of diseases associated with defects in alternative RNA splicing].

Postepy Hig Med Dosw (Online). 2012-9-18

引用本文的文献

[1]
Intron Retention and Alzheimer's Disease (AD): A Review of Regulation Genes Implicated in AD.

Genes (Basel). 2025-6-30

[2]
Regulated microexon alternative splicing in single neurons tunes synaptic function.

EMBO Rep. 2025-6-9

[3]
Dysregulated RNA-binding proteins and alternative splicing: Emerging roles in autism spectrum disorder.

Mol Cells. 2025-6-3

[4]
EML2 and EML4 splice variants regulate microtubule remodeling during neuronal cell differentiation.

J Biol Chem. 2025-5-19

[5]
Deep transcriptomics reveals cell-specific isoforms of pan-neuronal genes.

Nat Commun. 2025-5-16

[6]
Circular RNAs exhibit exceptional stability in the aging brain and serve as reliable age and experience indicators.

Cell Rep. 2025-4-22

[7]
Splicing to orchestrate cell fate.

Mol Ther Nucleic Acids. 2024-12-6

[8]
Deep Transcriptomics Reveals Cell-Specific Isoforms of Pan-Neuronal Genes.

bioRxiv. 2024-5-20

[9]
Single-cell long-read sequencing-based mapping reveals specialized splicing patterns in developing and adult mouse and human brain.

Nat Neurosci. 2024-6

[10]
Neuronal conversion from glia to replenish the lost neurons.

Neural Regen Res. 2024-7-1

本文引用的文献

[1]
Tissue-specific alternative splicing remodels protein-protein interaction networks.

Mol Cell. 2012-6-29

[2]
Tissue-specific splicing of disordered segments that embed binding motifs rewires protein interaction networks.

Mol Cell. 2012-6-29

[3]
A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels.

J Biol Chem. 2012-5-8

[4]
Deep sequencing the circadian and diurnal transcriptome of Drosophila brain.

Genome Res. 2012-4-3

[5]
Alternative splicing: decoding an expansive regulatory layer.

Curr Opin Cell Biol. 2012-3-30

[6]
DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.

Nature. 2012-3-25

[7]
The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

Genes Dev. 2012-2-22

[8]
Homeodomain protein otp and activity-dependent splicing modulate neuronal adaptation to stress.

Neuron. 2012-1-26

[9]
PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.

Nat Neurosci. 2012-1-15

[10]
SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1.

Cell. 2011-12-23

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