Norris Adam D, Calarco John A
FAS Center for Systems Biology, Harvard University Cambridge, MA, USA.
Front Neurosci. 2012 Aug 21;6:122. doi: 10.3389/fnins.2012.00122. eCollection 2012.
Alternative pre-mRNA splicing has the potential to greatly diversify the repertoire of transcripts in multicellular organisms. Increasing evidence suggests that this expansive layer of gene regulation plays a particularly important role in the development and function of the nervous system, one of the most complex organ systems found in nature. In this review, we highlight recent studies that continue to emphasize the influence and contribution of alternative splicing regulation to various aspects of neuronal development in addition to its role in the mature nervous system.
可变前体mRNA剪接有潜力极大地增加多细胞生物中转录本的种类。越来越多的证据表明，这一广泛的基因调控层面在神经系统的发育和功能中发挥着特别重要的作用，神经系统是自然界中最复杂的器官系统之一。在这篇综述中，我们重点介绍了近期的研究，这些研究除了强调可变剪接调控在成熟神经系统中的作用外，还继续强调其对神经元发育各个方面的影响和贡献。
