Vostrikov Victor, Uranova Natalya
Laboratory of Clinical Neuropathology, Mental Health Research Center, Moscow 115522, Russia.
Schizophr Res Treatment. 2011;2011:174689. doi: 10.1155/2011/174689. Epub 2011 Jul 3.
The postnatal maturation of the human prefrontal cortex is associated with substantial increase of number of oligodendrocytes. Previously, we reported decreased numerical density of oligodendrocytes in the prefrontal cortex in schizophrenia and mood disorders. To gain further understanding of the role oligodendrocytes in pathogenesis of schizophrenia and mood disorders, we examined the effect of the age on the number of oligodendrocytes in the prefrontal cortex in schizophrenia, bipolar disorder, and major depressive disorder. We revealed the age-related increase in numerical density of oligodendrocytes in layer VI and adjacent white matter of BA10 and BA 9 in normal controls but not in schizophrenia, bipolar disorder, and major depressive disorder. The absence of normal increase in the number of oligodendrocytes in gray and white matter with age in schizophrenia and mood disorders suggests that age-related process of oligodendrocyte increase is dysregulated in schizophrenia and mood disorders.
人类前额叶皮质的产后成熟与少突胶质细胞数量的显著增加有关。此前，我们报道过精神分裂症和情绪障碍患者前额叶皮质中少突胶质细胞的数量密度降低。为了进一步了解少突胶质细胞在精神分裂症和情绪障碍发病机制中的作用，我们研究了年龄对精神分裂症、双相情感障碍和重度抑郁症患者前额叶皮质中少突胶质细胞数量的影响。我们发现，在正常对照组中，BA10和BA9的VI层及相邻白质中少突胶质细胞的数量密度随年龄增长而增加，但在精神分裂症、双相情感障碍和重度抑郁症患者中并非如此。精神分裂症和情绪障碍患者的灰质和白质中少突胶质细胞数量未随年龄正常增加，这表明精神分裂症和情绪障碍中与年龄相关的少突胶质细胞增加过程失调。
