Laboratory of Clinical Neuropathology, Mental Health Research Centre, Kashirskoe shosse, 34, 115522, Moscow, Russia.
Eur Arch Psychiatry Clin Neurosci. 2022 Sep;272(6):947-955. doi: 10.1007/s00406-021-01353-w. Epub 2021 Nov 25.
Neuroimaging, genetic and molecular biological studies have shown impaired intra-cortical myelination in patients with schizophrenia, particularly in the prefrontal cortex. Previously we reported a significant deficit of oligodendrocytes and oligodendrocyte clusters in layers 3 and 5 of the prefrontal cortex, Brodmann area 10 (BA10) in schizophrenia. In this current study, we investigate the number of oligodendrocyte satellites (Sat-Ol) per pyramidal neuron in layer 5 of BA10 in schizophrenia (n = 17) as compared to healthy controls (n = 20) in the same section collection as previously used to study the numerical density (Nv) of oligodendrocytes and oligodendrocyte clusters. We find a significant reduction (- 39%, p < 0.001) in the number of Sat-Ol per neuron in schizophrenia as compared to the control group. The number of Sat-Ol per neuron did not correlate with the Nv of oligodendrocytes or with the Nv of oligodendrocyte clusters. Our previous studies of the inferior parietal lobule (BA39 and BA40), demonstrated significant decrease of the number of Sat-Ol only in patient subgroups with poor and fair insight. Additionally, correlation pattern between number of Sat-Ol and Nv of oligodendrocytes and oligodendrocyte clusters was similar between the two functionally interconnected cortical areas, BA10 and BA40, whereas in BA39, strong significant correlations were revealed between the number of Sat-Ol and Nv of oligodendrocyte clusters (0.9 ≤ R ≥ 0.66; p < 0.001). These data suggest that that specific features of Sat-Ol alterations patterns may be associated with specific activity-driven plasticity of corresponding networks in the brain of people with schizophrenia.
神经影像学、遗传学和分子生物学研究表明，精神分裂症患者皮质内髓鞘形成受损，尤其是前额皮质。我们之前报道过，精神分裂症患者前额皮质（Brodmann 区域 10，BA10）的 3 层和 5 层中少突胶质细胞和少突胶质细胞簇存在显著缺陷。在本研究中，我们在前一篇研究中使用的同一组织切片中，调查了 BA10 第 5 层每个锥体神经元的少突胶质细胞卫星（Sat-Ol）的数量，在精神分裂症患者（n=17）和健康对照组（n=20）之间进行比较。我们发现，与对照组相比，精神分裂症患者的 Sat-Ol 数量显著减少（-39%，p<0.001）。Sat-Ol 数量与少突胶质细胞的 Nv 或少突胶质细胞簇的 Nv 均无相关性。我们之前对下顶叶（BA39 和 BA40）的研究表明，仅在洞察力差和中等的患者亚组中，Sat-Ol 的数量才显著减少。此外，Sat-Ol 数量与少突胶质细胞和少突胶质细胞簇的 Nv 之间的相关模式在两个功能上相互连接的皮质区域（BA10 和 BA40）之间相似，而在 BA39 中，Sat-Ol 数量与少突胶质细胞簇的 Nv 之间存在强烈的显著相关性（0.9≤R≥0.66；p<0.001）。这些数据表明，Sat-Ol 改变模式的特定特征可能与精神分裂症患者大脑中相应网络的特定活动驱动的可塑性有关。
