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一名老年嗜铬细胞瘤患者反复发生泌尿道感染和心源性休克。

Recurrent urosepsis and cardiogenic shock in an elderly patient with pheochromocytoma.

作者信息

Khoo Joan Joo-Ching, Au Vanessa Shu-Chuan, Chen Richard Yuan-Tud

机构信息

Department of Endocrinology, Changi General Hospital, Singapore 529889.

出版信息

Case Rep Endocrinol. 2011;2011:759523. doi: 10.1155/2011/759523. Epub 2011 Sep 6.

Abstract

Pheochromocytomas are thought to be uncommon in the elderly. However, the prevalence is likely to be higher than reported, as older patients are less likely to be diagnosed due to absence of classical symptoms of sympathetic overactivity and confounding effects of aging, comorbidities, and medications. We describe a hypertensive elderly patient with incidentally diagnosed pheochromocytoma complicated by recurrent urosepsis, cardiomyopathy, and fatal myocardial infarction. Our case demonstrates that, in older hypertensive patients without classical symptoms, orthostatic hypotension and urinary retention, which are common in the elderly, may indicate catecholamine excess and that the deleterious cardiovascular consequences of catecholamine excess in the elderly are not prevented by pharmacological α- and β-blockade.

摘要

嗜铬细胞瘤在老年人中被认为并不常见。然而,其实际患病率可能高于报告的数字,因为老年患者由于缺乏交感神经过度活跃的典型症状以及衰老、合并症和药物的混杂影响,不太可能被诊断出来。我们描述了一位患有高血压的老年患者,其偶然被诊断出患有嗜铬细胞瘤,并伴有复发性泌尿道感染、心肌病和致命性心肌梗死。我们的病例表明,在没有典型症状的老年高血压患者中,老年人常见的体位性低血压和尿潴留可能提示儿茶酚胺过量,并且老年儿茶酚胺过量所带来的有害心血管后果无法通过药物α和β受体阻滞剂来预防。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/feda/3420517/deca07a11213/CRIM.ENDOCRINOLOGY2011-759523.001.jpg

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引用本文的文献

本文引用的文献

1
Cardiovascular complications in patients with pheochromocytoma: a mini-review.嗜铬细胞瘤患者的心血管并发症:小型综述。
Biomed Pharmacother. 2010 Sep;64(7):505-9. doi: 10.1016/j.biopha.2009.09.014. Epub 2009 Nov 17.
3
Clinical spectrum of pheochromocytoma.嗜铬细胞瘤的临床特征。
J Am Coll Surg. 2009 Dec;209(6):727-32. doi: 10.1016/j.jamcollsurg.2009.09.022.
5
Catecholamine-induced cardiomyopathy.儿茶酚胺诱导性心肌病
Endocr Pract. 2008 Dec;14(9):1137-49. doi: 10.4158/EP.14.9.1137.
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Phaeochromocytoma.嗜铬细胞瘤
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