Khoo Joan Joo-Ching, Au Vanessa Shu-Chuan, Chen Richard Yuan-Tud
Department of Endocrinology, Changi General Hospital, Singapore 529889.
Case Rep Endocrinol. 2011;2011:759523. doi: 10.1155/2011/759523. Epub 2011 Sep 6.
Pheochromocytomas are thought to be uncommon in the elderly. However, the prevalence is likely to be higher than reported, as older patients are less likely to be diagnosed due to absence of classical symptoms of sympathetic overactivity and confounding effects of aging, comorbidities, and medications. We describe a hypertensive elderly patient with incidentally diagnosed pheochromocytoma complicated by recurrent urosepsis, cardiomyopathy, and fatal myocardial infarction. Our case demonstrates that, in older hypertensive patients without classical symptoms, orthostatic hypotension and urinary retention, which are common in the elderly, may indicate catecholamine excess and that the deleterious cardiovascular consequences of catecholamine excess in the elderly are not prevented by pharmacological α- and β-blockade.
嗜铬细胞瘤在老年人中被认为并不常见。然而,其实际患病率可能高于报告的数字,因为老年患者由于缺乏交感神经过度活跃的典型症状以及衰老、合并症和药物的混杂影响,不太可能被诊断出来。我们描述了一位患有高血压的老年患者,其偶然被诊断出患有嗜铬细胞瘤,并伴有复发性泌尿道感染、心肌病和致命性心肌梗死。我们的病例表明,在没有典型症状的老年高血压患者中,老年人常见的体位性低血压和尿潴留可能提示儿茶酚胺过量,并且老年儿茶酚胺过量所带来的有害心血管后果无法通过药物α和β受体阻滞剂来预防。