Srivastava Rohit Kant, Agarwal Medhavi, Pundhir Ashish
Department of Psychiatry, Rohilkhand Medical College, Bareilly, Uttar Pradesh 243006, India.
Case Rep Psychiatry. 2011;2011:563204. doi: 10.1155/2011/563204. Epub 2011 Nov 17.
A woman consulted psychiatric Out-Patient Department (OPD) for her 5-year and 2-month-old son presenting with typical autistic symptoms like social, behavioural, and communicational ineptitudeness. Subsequent treatment with Donepezil resulted in marked improvement in the aforementioned symptomatology. Recent studies in autistic child have shown diminished acetylcholine and nicotinic receptor activity, thus an acetylcholinergic enhancer, Donepezil, likely accounts for improvement in autistic symptoms. Evidently, the case report consolidates Donepezil role as a potentially useful agent in the treatment of cognitive and behavioural symptoms observed in this disorder.
一名女性带着她5岁2个月大的儿子前往精神科门诊，孩子表现出典型的自闭症症状，如社交、行为和沟通能力不足。随后使用多奈哌齐进行治疗，上述症状有显著改善。最近针对自闭症儿童的研究表明，乙酰胆碱和烟碱受体活性降低，因此，一种乙酰胆碱能增强剂多奈哌齐可能是自闭症症状改善的原因。显然，该病例报告证实了多奈哌齐在治疗该疾病中所观察到的认知和行为症状方面具有潜在的治疗作用。
