• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一名接受依那西普治疗的类风湿关节炎患者随后发生肺孢子菌肺炎时的血清细胞因子浓度：病例报告

Serum cytokine concentrations in a patient with rheumatoid arthritis on etanercept therapy who subsequently developed pneumocystis pneumonia: a case report.

作者信息

Sato Masao, Takemura Masao, Shinohe Ryuki, Shimizu Katsuji

机构信息

Department of Orthopaedic Surgery, Gifu University School of Medicine, 1-1 Yanagido Gifu, Gifu 501-1194, Japan.

出版信息

Case Rep Rheumatol. 2011;2011:185657. doi: 10.1155/2011/185657. Epub 2011 Dec 15.

DOI:10.1155/2011/185657
PMID:22937439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3420776/
Abstract

We report a rheumatoid arthritis patient who was treated with etanercept. Serum levels of tumor-necrosis-factor- (TNF-) alpha, soluble-tumor-necrosis-factor receptor- (sTNFR-) I and -II, interleukin- (IL-) 6, and IL-1 beta were measured by ELISA before and during the course of therapy. While the serum levels of IL-6 and IL-1 beta dropped rapidly following the initiation of therapy, the concentrations of TNF-alpha and sTNFR-II steadily increased to a plateau. Although significant clinical efficacy was observed, etanercept had to be discontinued when after 12 weeks of therapy the patient was found to have pneumocystis pneumonia.

摘要

我们报告了一名接受依那西普治疗的类风湿性关节炎患者。在治疗前及治疗过程中，通过酶联免疫吸附测定法（ELISA）检测血清中肿瘤坏死因子-α（TNF-α）、可溶性肿瘤坏死因子受体-I（sTNFR-I）和-II（sTNFR-II）、白细胞介素-6（IL-6）以及白细胞介素-1β（IL-1β）的水平。治疗开始后，IL-6和IL-1β的血清水平迅速下降，而TNF-α和sTNFR-II的浓度则稳步上升至平台期。尽管观察到显著的临床疗效，但在治疗12周后患者被发现患有肺孢子菌肺炎，不得不停用依那西普。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163d/3420776/f52814940060/CRIM.RHEUMATOLOGY2011-185657.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163d/3420776/3d7d14e97bf1/CRIM.RHEUMATOLOGY2011-185657.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163d/3420776/e5041f3dd14d/CRIM.RHEUMATOLOGY2011-185657.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163d/3420776/5aaae2330805/CRIM.RHEUMATOLOGY2011-185657.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163d/3420776/f52814940060/CRIM.RHEUMATOLOGY2011-185657.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163d/3420776/3d7d14e97bf1/CRIM.RHEUMATOLOGY2011-185657.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163d/3420776/e5041f3dd14d/CRIM.RHEUMATOLOGY2011-185657.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163d/3420776/5aaae2330805/CRIM.RHEUMATOLOGY2011-185657.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/163d/3420776/f52814940060/CRIM.RHEUMATOLOGY2011-185657.004.jpg

相似文献

1
Serum cytokine concentrations in a patient with rheumatoid arthritis on etanercept therapy who subsequently developed pneumocystis pneumonia: a case report.一名接受依那西普治疗的类风湿关节炎患者随后发生肺孢子菌肺炎时的血清细胞因子浓度：病例报告
Case Rep Rheumatol. 2011;2011:185657. doi: 10.1155/2011/185657. Epub 2011 Dec 15.
2
Serum cytokines in juvenile rheumatoid arthritis. Correlation with conventional inflammation parameters and clinical subtypes.青少年类风湿关节炎中的血清细胞因子。与传统炎症参数及临床亚型的相关性。
Arthritis Rheum. 1995 Feb;38(2):211-20. doi: 10.1002/art.1780380209.
3
Analysis of tumor necrosis factor-alpha, interleukin-6, interleukin-1beta, soluble tumor necrosis factor receptors I and II, interleukin-6 soluble receptor, interleukin-1 soluble receptor type II, interleukin-1 receptor antagonist, and protein in the synovial fluid of patients with temporomandibular joint disorders.颞下颌关节紊乱病患者滑液中肿瘤坏死因子-α、白细胞介素-6、白细胞介素-1β、可溶性肿瘤坏死因子受体I和II、白细胞介素-6可溶性受体、白细胞介素-1可溶性受体II型、白细胞介素-1受体拮抗剂及蛋白质的分析
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005 Mar;99(3):276-84. doi: 10.1016/j.tripleo.2004.06.074.
4
Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating concentrations of cytokines and their antagonists. Longitudinal evaluation in patients with rheumatoid arthritis.甲氨蝶呤单独或联合柳氮磺胺吡啶对细胞因子及其拮抗剂产生和循环浓度的影响。类风湿关节炎患者的纵向评估。
Br J Rheumatol. 1995 Aug;34(8):747-55. doi: 10.1093/rheumatology/34.8.747.
5
Serum chemokines in patients with rheumatoid arthritis treated with etanercept.类风湿关节炎患者接受依那西普治疗后的血清趋化因子。
Rheumatol Int. 2011 Apr;31(4):457-61. doi: 10.1007/s00296-009-1299-3. Epub 2009 Dec 19.
6
Etanercept reduces the serum levels of interleukin-23 and macrophage inflammatory protein-3 alpha in patients with rheumatoid arthritis.依那西普可降低类风湿关节炎患者的血清白细胞介素-23和巨噬细胞炎性蛋白-3α水平。
Rheumatol Int. 2007 Dec;28(2):137-43. doi: 10.1007/s00296-007-0388-4. Epub 2007 Jul 10.
7
The impact of disease activity and tumour necrosis factor-α inhibitor therapy on cytokine levels in juvenile idiopathic arthritis.疾病活动度和肿瘤坏死因子-α抑制剂治疗对幼年特发性关节炎细胞因子水平的影响。
Clin Exp Immunol. 2016 Jun;184(3):308-17. doi: 10.1111/cei.12782. Epub 2016 Apr 13.
8
Etanercept treatment reduces the serum levels of interleukin-15 and interferon-gamma inducible protein-10 in patients with rheumatoid arthritis.依那西普治疗可降低类风湿关节炎患者血清中白细胞介素-15 和干扰素-γ诱导蛋白-10 的水平。
Rheumatol Int. 2010 Apr;30(6):725-30. doi: 10.1007/s00296-009-1356-y. Epub 2010 Jan 10.
9
Circulating soluble tumor necrosis factor receptors, interleukin-2 receptors, tumor necrosis factor alpha, and interleukin-6 levels in rheumatoid arthritis. Longitudinal evaluation during methotrexate and azathioprine therapy.类风湿关节炎患者循环中可溶性肿瘤坏死因子受体、白细胞介素-2受体、肿瘤坏死因子α及白细胞介素-6水平。甲氨蝶呤和硫唑嘌呤治疗期间的纵向评估。
Arthritis Rheum. 1993 Aug;36(8):1070-9. doi: 10.1002/art.1780360807.
10
Soluble cytokine receptors sTNFR I and sTNFR II, receptor antagonist IL-1ra, and anti-inflammatory cytokines IL-10 and IL-13 in the pathogenesis of systemic inflammatory response syndrome in the course of burns in children.可溶性细胞因子受体sTNFR I和sTNFR II、受体拮抗剂IL-1ra以及抗炎细胞因子IL-10和IL-13在儿童烧伤过程中全身炎症反应综合征发病机制中的作用
Med Sci Monit. 2009 Jan;15(1):CR26-31.

引用本文的文献

1
Comprehensive molecular and clinical analysis of adalimumab and etanercept therapeutic potential in patients with psoriatic arthritis.阿达木单抗和依那西普治疗银屑病关节炎患者的疗效的综合分子与临床分析
Postepy Dermatol Alergol. 2020 Apr;37(2):262-268. doi: 10.5114/ada.2020.94847. Epub 2020 May 6.

本文引用的文献

1
Identification of acute phase reactants and cytokines useful for monitoring infliximab therapy in ankylosing spondylitis.鉴定可用于监测强直性脊柱炎英夫利昔单抗治疗的急性期反应物和细胞因子。
Clin Rheumatol. 2008 Nov;27(11):1429-35. doi: 10.1007/s10067-008-0941-x. Epub 2008 Jun 20.
2
Impact of treatment with infliximab on serum cytokine profile of patients with rheumatoid and psoriatic arthritis.英夫利昔单抗治疗对类风湿性关节炎和银屑病关节炎患者血清细胞因子谱的影响。
Ann N Y Acad Sci. 2007 Sep;1110:649-60. doi: 10.1196/annals.1423.068.
3
Pharmacokinetics, efficacy, and safety of short-term (12 weeks) etanercept for methotrexate-refractory polyarticular juvenile idiopathic arthritis in Japan.
日本短期（12周）使用依那西普治疗甲氨蝶呤难治性多关节型幼年特发性关节炎的药代动力学、疗效及安全性
Mod Rheumatol. 2005;15(6):397-404. doi: 10.1007/s10165-005-0431-9.
4
Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register.类风湿关节炎患者中抗TNF-α治疗反应的预测因素：来自英国风湿病学会生物制剂登记处的结果
Rheumatology (Oxford). 2006 Dec;45(12):1558-65. doi: 10.1093/rheumatology/kel149. Epub 2006 May 16.
5
Guidelines for the proper use of etanercept in Japan.日本依那西普合理使用指南。
Mod Rheumatol. 2006;16(2):63-7. doi: 10.1007/s10165-006-0457-7.
6
Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized trial.依那西普与甲氨蝶呤单药及联合用药治疗类风湿关节炎的比较：TEMPO研究的两年临床和影像学结果，一项双盲随机试验
Arthritis Rheum. 2006 Apr;54(4):1063-74. doi: 10.1002/art.21655.
7
A phase II study of etanercept (Enbrel), a tumor necrosis factor alpha inhibitor in patients with metastatic breast cancer.一项针对转移性乳腺癌患者使用肿瘤坏死因子α抑制剂依那西普（恩利）的II期研究。
Clin Cancer Res. 2004 Oct 1;10(19):6528-34. doi: 10.1158/1078-0432.CCR-04-0730.
8
Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial.与单药治疗相比，依那西普与甲氨蝶呤联合治疗类风湿关节炎患者的疗效：双盲随机对照试验
Lancet. 2004 Feb 28;363(9410):675-81. doi: 10.1016/S0140-6736(04)15640-7.
9
Development of anti-TNF therapy for rheumatoid arthritis.类风湿关节炎抗 TNF 治疗的发展
Nat Rev Immunol. 2002 May;2(5):364-71. doi: 10.1038/nri802.
10
Etanercept in rheumatoid arthritis.类风湿关节炎中的依那西普
Expert Opin Pharmacother. 2001 Jul;2(7):1137-48. doi: 10.1517/14656566.2.7.1137.