Prener A, Carstensen B
Danish Cancer Registry, Institute of Cancer Epidemiology, Copenhagen.
Am J Epidemiol. 1990 Jan;131(1):15-9. doi: 10.1093/oxfordjournals.aje.a115468.
On the basis of 40 years of national cancer registration, the authors analyzed the distribution of birth dates of patients with testicular cancer in the Danish male population, which has a particularly high incidence of this cancer. No significant peaks were identified, except for men with embryonal carcinomas born between 1950 and 1959, for whom a significant 12-month cycle was observed. This result differs from those of earlier studies. The number of cases of embryonal carcinomas in the 1950-1959 birth cohort is small, but it is possible that an etiologic factor that varies with season was present at the time. For all testicular cancers and for the three histologic subgroups analyzed, the authors found significant 2-month cycles. The biologic relevance of a 2-month cycle is not clear. It is concluded that there is little evidence to support the hypothesis of a systematic variation in month of birth among men with testicular cancer.
基于40年的国家癌症登记数据，作者分析了丹麦男性人群中睾丸癌患者的出生日期分布情况，该国睾丸癌发病率特别高。除了1950年至1959年出生的胚胎癌男性患者观察到显著的12个月周期外，未发现显著峰值。这一结果与早期研究不同。1950 - 1959年出生队列中的胚胎癌病例数较少，但当时可能存在随季节变化的病因因素。对于所有睾丸癌以及所分析的三个组织学亚组，作者发现了显著的2个月周期。2个月周期的生物学相关性尚不清楚。结论是，几乎没有证据支持睾丸癌男性患者出生月份存在系统性变化这一假设。
