Erichsen A
Patologisk anatomisk laboratorium Aker sykehus, Oslo.
Tidsskr Nor Laegeforen. 1990 Aug 20;110(19):2541-3.
An increasing incidence of testicular germ cell tumours has been observed in many white populations in this century. Ethnic genetic implications and lifestyle seem to influence the development of testicular cancers, whereas the influence of intrauterine conditions is under debate. Epidemiologic studies cannot explain the increasing incidence among young men. The age variation of incidence and histologic type indicates at least two different aetiological mechanisms. Testicular cancers among young men are most probably due to gonadal dysgenesis, whereas in old men they reflect the general increased risk of cancer with old age. The increased risk of developing testicular germ cell tumours among cryptorchid young men supports the gonadal dysgenesy hypothesis.
本世纪以来,在许多白人人群中观察到睾丸生殖细胞肿瘤的发病率呈上升趋势。种族遗传因素和生活方式似乎会影响睾丸癌的发生,而子宫内环境的影响仍存在争议。流行病学研究无法解释年轻男性中发病率上升的现象。发病率和组织学类型的年龄差异表明至少存在两种不同的病因机制。年轻男性中的睾丸癌很可能是由于性腺发育不全,而老年男性中的睾丸癌则反映了随着年龄增长患癌风险的普遍增加。隐睾年轻男性发生睾丸生殖细胞肿瘤的风险增加支持了性腺发育不全假说。