缺血再灌注损伤中的微小RNA
MicroRNAs in ischemia-reperfusion injury.
作者信息
Weiss Jakob Bw, Eisenhardt Steffen U, Stark G Björn, Bode Christoph, Moser Martin, Grundmann Sebastian
出版信息
Am J Cardiovasc Dis. 2012;2(3):237-47. Epub 2012 Jul 25.
Abstract
Ischemia-reperfusion injury (IRI) is a major causal factor of tissue injury in various clinical settings including myocardial infarction, stroke, and free microsurgical tissue transfer. MicroRNAs (miRNAs, miRs) are short, non-coding RNA molecules involved in post-transcriptional regulation of gene expression. During the last years they have emerged as regulators of IRI as well as ischemic preconditioning and ischemic postconditioning. Here we give an overview of the current literature and describe the potential use of miRNA-based therapeutics for the treatment and prevention of ischemia-reperfusion injury in the future.
摘要
缺血再灌注损伤（IRI）是包括心肌梗死、中风和游离显微外科组织移植在内的各种临床环境中组织损伤的主要致病因素。微小RNA（miRNA，miR）是参与基因表达转录后调控的短链非编码RNA分子。在过去几年中，它们已成为IRI以及缺血预处理和缺血后处理的调节因子。在此，我们概述当前的文献，并描述基于miRNA的疗法在未来治疗和预防缺血再灌注损伤中的潜在用途。
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