Han Bao-Lin, Xu Xiang-Ying, Zhang Chun-Zhi, Wu Jian-Juan, Han Chun-Feng, Wang Hui, Wang Xuan, Wang Guang-Shun, Yang Shu-Juan, Xie Yao
Tianjin Baodi Hospital, Tianjin, China.
Asian Pac J Cancer Prev. 2012;13(6):2577-81. doi: 10.7314/apjcp.2012.13.6.2577.
To conduct a meta-analysis to investigate the value of EBV DNA in diagnosis of nasopharyngeal cancer (NPC) in Asian populations, and provide important evidence for screening.
Prospective or respective case-control or cohort studies regarding the detection role of EBV DNA for NPC were included in our study. We conducted a comprehensive literature search in PubMed, EMBASE, and the Chinese Biomedical Database (CBM database between January 1980 and March 2012.
A total of 18 studies with 1492 NPC cases and 2641 health controls were included. Almost of the included studies were conducted in China, and only one other conducted in Thailand. The overall results demonstrated that the pooled sensitivity, specificity, positive likelihood (+ LR) and negative likelihood (-LR) were 0.73 (0.71-0.75), 0.89 (0.88-0.90), 8.84 (5.65-13.84) and 0.19(0.11-0.32), respectively. The overall EBV DNA detection showed the largest area of 0.932 under the summary receiver operator curve (SROC). The accuracy of detection by plasma for NPC (0.86) was higher than in serum (0.81), with largest areas under the SROC of 0.97 and 0.91, respectively.
Our results demonstrated the EBV DNA detection in plasma or serum has high sensitivity and specificity in diagnosis of NPC, especially in Chinese populations with a high risk of cancer.
进行一项荟萃分析，以研究EBV DNA在亚洲人群鼻咽癌（NPC）诊断中的价值，并为筛查提供重要依据。
纳入有关EBV DNA对NPC检测作用的前瞻性或回顾性病例对照或队列研究。我们于1980年1月至2012年3月期间在PubMed、EMBASE和中国生物医学数据库（CBM数据库）中进行了全面的文献检索。
共纳入18项研究，包括1492例NPC病例和2641例健康对照。几乎所有纳入研究均在中国进行，仅有一项在泰国进行。总体结果显示，合并敏感度、特异度、阳性似然比（+LR）和阴性似然比（-LR）分别为0.73（0.71 - 0.75）、0.89（0.88 - 0.90）、8.84（5.65 - 13.84）和0.19（0.11 - 0.32）。EBV DNA总体检测在汇总受试者工作特征曲线（SROC）下的最大面积为0.932。血浆检测NPC的准确性（0.86）高于血清（0.81），SROC下的最大面积分别为0.97和0.91。
我们的结果表明，血浆或血清中EBV DNA检测在NPC诊断中具有高敏感度和特异度，尤其在癌症高风险的中国人群中。
