Department of Pathology, Telemark Hospital, Skien, Norway.
Department of Pathology, University Clinic Hospital-INCLIVA, University of Valencia, Valencia, Spain.
Adv Exp Med Biol. 2021;1302:113-132. doi: 10.1007/978-3-030-62658-7_9.
Chemokines are a group of small proteins which play an important role in leukocyte migration and invasion. They are also involved in the cellular proliferation and migration of tumor cells.Chemokine CCL27 (cutaneous T cell-attracting chemokine, CTACK) is mainly expressed by keratinocytes of the normal epidermis. It is well known that this chemokine plays an important role in several inflammatory diseases of the skin, such as atopic dermatitis, contact dermatitis, and psoriasis. Moreover, several studies have shown an association between CCL27 expression and a variety of neoplasms including skin cancer.In this chapter, we address the role of chemokine CCL27 in the tumor microenvironment in the most relevant cancers of the skin and other anatomical locations. We also make a brief comment on future perspectives and the potential relation of CCL27 with different immunotherapeutic modalities.
趋化因子是一组在白细胞迁移和浸润中起重要作用的小蛋白。它们还参与肿瘤细胞的增殖和迁移。趋化因子 CCL27（皮肤 T 细胞吸引趋化因子，CTACK）主要由正常表皮的角质形成细胞表达。众所周知，这种趋化因子在几种皮肤炎症性疾病中起重要作用，如特应性皮炎、接触性皮炎和银屑病。此外，多项研究表明 CCL27 表达与多种包括皮肤癌在内的肿瘤之间存在关联。在本章中，我们将讨论趋化因子 CCL27 在皮肤和其他解剖部位最相关的癌症的肿瘤微环境中的作用。我们还简要讨论了未来的展望以及 CCL27 与不同免疫治疗方式的潜在关系。
