Arguello F, Baggs R B, Duerst R E, Johnstone L, McQueen K, Frantz C N
Department of Pediatrics, University of Rochester School of Medicine and Dentistry, NY 14642.
Cancer. 1990 Jan 1;65(1):98-106. doi: 10.1002/1097-0142(19900101)65:1<98::aid-cncr2820650121>3.0.co;2-k.
The authors have studied the sequential events in the process of vertebral metastasis that result in spinal cord compression. Different tumor cell lines were injected into the systemic arterial circulation of syngeneic or nude mice, and they were killed at timed intervals after injection or when they became paraplegic. The following observations were made. The tumor cells lodged and grew in the hematopoietic bone marrow of the vertebrae. Cancer cells in the vertebral marrow cavity invaded into the spinal canal through the foramina of the vertebral veins rather than destroying the cortical bone. Tumor cell lines that grew in an infiltrative fashion migrated toward a posterior location in the spinal canal, and compressed the spinal cord from a posterior direction. Tumor cell lines that grew as compact tumors formed a tumor mass at the same location from which the cells emerged from the vertebra, and compressed the cord predominantly from an anterior direction. Radiographic evidence of vertebral metastasis was a late event, and commonly associated with significant compression of the cord and extraosseous tumor. These experimental findings may help to establish better diagnostic and treatment strategies for patients with metastatic disease of the spine.
作者研究了导致脊髓压迫的椎体转移过程中的一系列事件。将不同的肿瘤细胞系注入同基因或裸鼠的体循环动脉中，并在注射后的特定时间间隔或当它们出现截瘫时将其处死。得出以下观察结果。肿瘤细胞在椎骨的造血骨髓中着床并生长。椎骨髓腔内的癌细胞通过椎静脉孔侵入椎管，而不是破坏皮质骨。以浸润方式生长的肿瘤细胞系向椎管后方迁移，并从后方压迫脊髓。以致密肿瘤形式生长的肿瘤细胞系在细胞从椎体出现的同一位置形成肿瘤块，并主要从前方压迫脊髓。椎体转移的影像学证据是一个晚期事件，通常与脊髓的严重压迫和骨外肿瘤有关。这些实验结果可能有助于为脊柱转移性疾病患者制定更好的诊断和治疗策略。
