CHU de Caen, Service de Microbiologie, F-14033 Caen, France.
Diagn Microbiol Infect Dis. 2012 Nov;74(3):236-41. doi: 10.1016/j.diagmicrobio.2012.07.001. Epub 2012 Aug 29.
The purpose of this retrospective study was to evaluate the pathogenic role of Corynebacterium species in lower respiratory tract infections as well as their routine laboratory investigation. From April 2007 to August 2009, 27 clinical isolates were significantly recovered from respiratory specimens of 27 different patients clinically suspected of having lower respiratory tract infections. The average age of patients was 65 years, while 22 (81%) patients presented at least 1 predisposing condition. Of the 27 patients, 15 (56%) were classified as infected according to Centers for Disease Control and Prevention/National Healthcare Safety Network criteria, with 93% of infections being hospital acquired. All isolates were accurately identified to the species level using molecular methods (i.e., 17 Corynebacterium pseudodiphtheriticum, 7 Corynebacterium striatum, and 3 Corynebacterium accolens), whereas phenotypic methods remained frequently unreliable for identifying C. striatum and C. accolens strains. All tested isolates were susceptible to amoxicillin, imipenem, vancomycin, linezolid, and tigecycline, whereas most of them were resistant to erythromycin.
本回顾性研究旨在评估棒状杆菌属在呼吸道感染中的致病作用及其常规实验室研究。2007 年 4 月至 2009 年 8 月，从 27 名临床疑似患有下呼吸道感染的患者的呼吸道标本中显著分离出 27 株临床分离株。患者的平均年龄为 65 岁，22 名（81%）患者至少存在 1 种易感因素。根据疾病控制和预防中心/国家医疗保健安全网络标准，27 名患者中有 15 名（56%）被归类为感染，其中 93%的感染为医院获得性感染。所有分离株均通过分子方法准确鉴定到种水平（即 17 株假白喉棒状杆菌、7 株纹带棒状杆菌和 3 株痤疮棒状杆菌），而表型方法在鉴定纹带棒状杆菌和痤疮棒状杆菌株时仍然经常不可靠。所有测试的分离株均对阿莫西林、亚胺培南、万古霉素、利奈唑胺和替加环素敏感，而大多数对红霉素耐药。
