Wang Junrui, Wang Yanyan, Du Xiaoli, Cui Jinghua, Wang Kai, Zhang Lipeng, Han Yanqiu
Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
J Infect Dev Ctries. 2016 Dec 30;10(12):1299-1305. doi: 10.3855/jidc.7577.
With increasing reports about Corynebacterium striatum, its potential pathogenicity and clinical significance are drawing more attention in recent years.
During a 14-month period, Corynebacterium striatum strains were routinely isolated in lower respiratory tract samples of the inpatients in a tertiary hospital in China, and the suspected isolates were identified with VITEK-2 ANC card and 16S rRNA sequencing technique, respectively. Pulsed-field gel electrophoresis (PFGE) was employed to discriminate different clones, and biofilm-producing abilities of different strains were compared.
A total of 82 strains of Corynebacterium striatum were mainly isolated from neurosurgery patients (45.1%, 37/82). Three epidemic clones (type D, F, and I) were identified, accounting for 82.9% (68/82) of strains. All 82 C. striatum strains were all sensitive to vancomycin, and resistant to ceftriaxone, imipenem, and ciprofloxacin. One week before C. striatum isolation, 89.0% (73/82) patients showed lower levels of hemoglobin, 93.9% (77/82) of patients received treatment of several kinds of antibiotics, and 41.5% (34/82) patients with glucocorticoid, and 46.3% (38/82) of patients showed disturbed consciousness at different levels.
Corynebacterium striatum strains isolated during this study were mainly multidrug resistant, and the predominant clones could rapidly transmit among susceptible inpatients. Corynebacterium striatum seems to be an important pathogen for patients with specific risk factors, especially for the ones with lower hemoglobin levels who are being treated with broad-spectrum antibiotics.
随着关于纹带棒状杆菌的报道日益增多，其潜在致病性和临床意义近年来受到更多关注。
在14个月期间，从中国一家三级医院住院患者的下呼吸道样本中常规分离出纹带棒状杆菌菌株，分别使用VITEK-2 ANC卡和16S rRNA测序技术对疑似分离株进行鉴定。采用脉冲场凝胶电泳（PFGE）鉴别不同克隆，并比较不同菌株的生物膜形成能力。
共分离出82株纹带棒状杆菌，主要来自神经外科患者（45.1%，37/82）。鉴定出三个流行克隆（D型、F型和I型），占菌株的82.9%（68/82）。所有82株纹带棒状杆菌均对万古霉素敏感，对头孢曲松、亚胺培南和环丙沙星耐药。在分离出纹带棒状杆菌前一周，89.0%（73/82）的患者血红蛋白水平较低，93.9%（77/82）的患者接受了多种抗生素治疗，41.5%（34/82）的患者使用了糖皮质激素，46.3%（38/82）的患者存在不同程度的意识障碍。
本研究中分离出的纹带棒状杆菌菌株主要为多重耐药，优势克隆可在易感住院患者中迅速传播。纹带棒状杆菌似乎是具有特定危险因素患者的重要病原体，尤其是血红蛋白水平较低且正在接受广谱抗生素治疗的患者。
