Department of Obstetrics and Gynecology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan.
J Endocrinol Invest. 2013 Dec;36(11):982-5. doi: 10.3275/9001. Epub 2013 Jun 10.
High-molecular weight (HMW) isoform level and HMW ratio have been shown to be better predictors of insulin sensitivity and metabolic syndrome than total adiponectin level.We examined the changes in circulating levels of HMW adiponectin and ratios of HMW to total adiponectin in women during the menopausal transition.
We conducted a cross-sectional study in 217 healthy women and divided them into 4 stages: 58 women in pre-menopausal, 69 women in perimenopausal, 62 women in early post-menopausal and 28 women in late post-menopausal phase. Serum levels of total adiponectin and HMW adiponectin were measured by an enzyme-linked immunosorbent assay.
In late post-menopausal women, HMW adiponectin level was significantly higher than that in peri-menopausal women and the HMW to total adiponectin ratio was significantly lower than that in early post-menopausal women. In peri-menopausal women, HMW adiponectin level was significantly lower than that in pre-menopausal women and HMW to total adiponectin ratio was significantly lower than the ratios in pre-menopausal and early post-menopausal women.
The ratio of HMW to total adiponectin is low in late post-menopausal women, though both levels of total and HMW adiponectin were high after menopause in our cross-sectional study.
高分子量（HMW）亚型水平和 HMW 比值比总脂联素水平更能预测胰岛素敏感性和代谢综合征。我们研究了绝经过渡期间女性循环中 HMW 脂联素水平和 HMW 与总脂联素比值的变化。
我们对 217 名健康女性进行了横断面研究，并将其分为 4 个阶段：58 名处于绝经前，69 名处于围绝经期，62 名处于绝经早期，28 名处于绝经后期。采用酶联免疫吸附试验测定总脂联素和 HMW 脂联素的血清水平。
在绝经后期妇女中，HMW 脂联素水平明显高于围绝经期妇女，HMW 与总脂联素的比值明显低于绝经早期妇女。在围绝经期妇女中，HMW 脂联素水平明显低于绝经前妇女，HMW 与总脂联素的比值明显低于绝经前和绝经早期妇女。
尽管在我们的横断面研究中，绝经后总脂联素和 HMW 脂联素水平均升高，但绝经后晚期女性 HMW 与总脂联素的比值较低。
