Asgharnia Maryam, Faraji Roya, Mirhaghjoo Nooshaz, Atrkar Roshan Zahra, Ashrafkhani Babak, Moslehi Mina
Reproductive Health Research Center, Department of Obstetrics and Gynecology, Guilan University of Medical Sciences, Rasht, Iran.
Department of Midwifery, Guilan University of Medical Sciences, Rasht, Iran.
Iran J Reprod Med. 2013 Aug;11(8):647-52.
Measuring the 24-hour urine protein ≥300 mg is the standard threshold value for diagnosis of preeclampsia.
This study was intended to determine if a patient's 4-hour urine protein correlate with the 24-hour value for diagnosis of preeclampsia.
This was a cross sectional study performed on 84 women with suspected preeclampsia due to positive urinary test strip with minimum protein content of 1+ and BP ≥140/90 at Al-zahra Educational Hospital in Rasht (Iran) from May 2007 to January 2008. Urine samples were collected within 24 hours in successive periods: The first 4-hour and the next 20-hours urine, in separate containers. The protein contents of 4-hour and 24-hour urine samples were calculated. Data were analyzed by intra-class correlation coefficient, and Receiver Operating Characteristic (ROC) curve.
The ROC curve showed the cut-off point of 55.5 for 4-hour urine protein. The correlation between 4- and 24-hour urine protein excretions identified that most women (about 85.1%) with protein excretion rate of 300 mg/24h or more (with preeclampsia) had the same amount of protein of 55.5 or more in their 4-hour urine excretion (p<0.001). Also, most of them (about 83.7%) with a total urinary protein excretion of less than 300 mg/24h (no preeclampsia) had a protein excretion rate of less than 55.5 mg/4h.
This study showed 4-hour protein collection can be used as acceptable substitute for assessing the protein content of 24-hour urine samples as a more convenient, faster, and cheaper method for diagnosis of preeclampsia and the cut-off point for 4-hour urine protein is 55.5 mg. This article extracted from a submitted thesis. (Mina Moslehi).
测量24小时尿蛋白≥300毫克是诊断先兆子痫的标准阈值。
本研究旨在确定患者的4小时尿蛋白是否与诊断先兆子痫的24小时值相关。
这是一项横断面研究，于2007年5月至2008年1月在伊朗拉什特的阿尔扎赫拉教育医院对84名疑似先兆子痫的女性进行，这些女性尿试纸检测呈阳性，最低蛋白含量为1+且血压≥140/90。在24小时内分阶段收集尿液样本：最初的4小时尿液和接下来的20小时尿液，分别装在不同容器中。计算4小时和24小时尿液样本的蛋白含量。通过组内相关系数和受试者工作特征（ROC）曲线分析数据。
ROC曲线显示4小时尿蛋白的截断点为55.5。4小时和24小时尿蛋白排泄量之间的相关性表明，大多数24小时尿蛋白排泄率为300毫克或更高（患有先兆子痫）的女性，其4小时尿排泄中的蛋白量为55.5或更高（p<0.001）。此外，大多数24小时尿蛋白总排泄量低于300毫克（无先兆子痫）的女性，其4小时尿蛋白排泄率低于55.5毫克/4小时。
本研究表明，收集4小时尿蛋白可作为评估24小时尿样本蛋白含量的可接受替代方法，是一种更方便、快捷且便宜的先兆子痫诊断方法，4小时尿蛋白的截断点为55.5毫克。本文摘自一篇提交的论文。（米娜·莫斯莱希）
