State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, No. 5 Xinmofan Road, Nanjing 210009, People's Republic of China.
Biotechnol Adv. 2012 Nov-Dec;30(6):1685-96. doi: 10.1016/j.biotechadv.2012.08.007. Epub 2012 Aug 23.
The growing concern about the safety of food and dairy additives and the increasing costs of petroleum-based chemicals have rekindled the interest in the fermentation processes for fumaric acid production. The key problems of the industrial production of microbial fumaric acid are reviewed in this paper. Various strategies, including strain improvement, morphology control, substrate choice, fermentation process and separation process, are summarized and compared, and their economical possibilities for industrial processes are discussed. The market prospects and technological strategies for value-added fumaric acid derivatives are also addressed. The future prospects of microbial fumaric acid production are proposed at the end of this article.
人们对食品和奶制品添加剂安全性的日益关注，以及石油基化学品成本的不断增加，重新燃起了人们对富马酸发酵生产工艺的兴趣。本文综述了微生物富马酸工业生产中的关键问题。总结并比较了各种策略，包括菌株改良、形态控制、底物选择、发酵工艺和分离工艺，并讨论了它们在工业过程中的经济可行性。还讨论了富马酸衍生物的市场前景和技术策略。本文最后提出了微生物富马酸生产的未来展望。
