Division of Gynecologic Oncology, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Gynecol Oncol. 2012 Dec;127(3):616-9. doi: 10.1016/j.ygyno.2012.08.025. Epub 2012 Aug 29.
The incidence for uterine cancers has been reported to be higher among white women, whereas mortality is higher among black women. Reasons for the higher mortality among black women are not completely understood. The aim of our study is to examine the relationship between race/ethnicity, histopathologic subtype, and survival in uterine cancer.
We abstracted socio-demographic, treatment, and survival data for all women who were diagnosed with uterine cancer at Montefiore Medical Center from January 1999 through December 2009. Pathology records were reviewed.
984 patients were identified. Racial/ethnic distribution was 382 (39%) white, 308 (31%) black, 232 (24%) Hispanic, and 62 (6.3%) other races, mixed, or unknown. 592 (60%) patients had endometrioid histology. Blacks were much more likely than whites to have non-endometrioid histologies (p<0.001), including papillary serous, carcinosarcoma, and leiomyosarcoma. Blacks and Hispanics were at least as likely as whites to receive either chemotherapy or radiation therapy. The hazard ratio for death for black versus white patients was 1.94 (p<0.001) when all histological subtypes were included. The hazard ratio for Hispanics for death was 1.2 (p=0.32) compared to whites. However, when patients were divided into endometrioid and non-endometrioid histological subtypes, there was no significant difference in survival by race/ethnicity.
Black patients with uterine cancer are much more likely to die and are much more likely to have non-endometrioid histologies than white patients. There are no differences in survival among white, black, or Hispanic women with uterine cancer, after control for histological subtype.
据报道，白人女性的子宫癌发病率较高，而黑人女性的死亡率较高。导致黑人女性死亡率较高的原因尚不完全清楚。我们的研究旨在探讨种族/民族、组织病理学亚型与子宫癌生存之间的关系。
我们从 1999 年 1 月至 2009 年 12 月，在 Montefiore 医疗中心，对所有被诊断患有子宫癌的女性的社会人口统计学、治疗和生存数据进行了摘要。对病理记录进行了审查。
共确定了 984 名患者。种族/民族分布为 382 名（39%）白人、308 名（31%）黑人、232 名（24%）西班牙裔、62 名（6.3%）其他种族、混合或未知。592 名（60%）患者具有子宫内膜样组织学特征。与白人相比，黑人更有可能患有非子宫内膜样组织学类型（p<0.001），包括乳头状浆液性、癌肉瘤和平滑肌肉瘤。黑人患者和西班牙裔患者接受化疗或放疗的可能性与白人患者至少一样大。将所有组织学类型包括在内时，黑种人患者死亡的风险比白人患者高 1.94（p<0.001）。与白人相比，西班牙裔患者的死亡风险比为 1.2（p=0.32）。然而，当患者被分为子宫内膜样和非子宫内膜样组织学类型时，种族/民族对生存没有显著影响。
与白人患者相比，患有子宫癌的黑人患者更有可能死亡，且更有可能患有非子宫内膜样组织学类型。在控制组织学类型后，患有子宫癌的白人、黑人和西班牙裔女性之间的生存无差异。
