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丹麦吸烟禁令对急性心肌梗死住院人数的影响。

The impact of the Danish smoking ban on hospital admissions for acute myocardial infarction.

作者信息

Christensen Tabita Maria, Møller Lisbeth, Jørgensen Torben, Pisinger Charlotta

机构信息

Faculty of Health Sciences, University of Copenhagen, Denmark.

出版信息

Eur J Prev Cardiol. 2014 Jan;21(1):65-73. doi: 10.1177/2047487312460213. Epub 2012 Aug 31.

Abstract

BACKGROUND

Exposure to secondhand smoke is associated with an increased risk of acute myocardial infarction (AMI). The positive impact of a smoking ban on AMI hospitalization rates has been demonstrated both inside and outside Europe. A national smoking ban (SB) was implemented in Denmark on 15 August 2007.

PURPOSE

To evaluate the impact of the Danish SB on hospital admissions for AMI.

METHODS

Poisson regression models were used to analyse changes over time in AMI-admissions in Denmark. We investigated a seven year period: five years before and two years after implementation of the SB. We accounted for the variation in the population size and for seasonal trends. Potential confounders included were: gender, age and the incidence of type 2 diabetes (T2D).

RESULTS

A significant reduction in the number of AMI-admissions was found in the last three years of the study period after adjusting for the potential confounders. The significant reductions were found one year before the SB (relative rate (RR) = 0.86, 95% confidence interval (CI) 0.79-0.94), one year after the SB (RR = 0.77, 95% CI 0.71-0.85) and two years after the SB (RR = 0.77, 95% CI 0.70-0.84).

CONCLUSIONS

A significant reduction in the number of AMI-admissions was found already one year before the SB after adjustment for the incidence of T2D. The results differ from most results found in similar studies throughout the world and may be explained by the incremental enactment of SBs in Denmark and the implementation of a nation-wide ban on industrially produced trans-fatty acids in food in 2004.

摘要

背景

接触二手烟与急性心肌梗死(AMI)风险增加相关。在欧洲内外,吸烟禁令对AMI住院率的积极影响均已得到证实。丹麦于2007年8月15日实施了全国性吸烟禁令(SB)。

目的

评估丹麦吸烟禁令对AMI住院情况的影响。

方法

采用泊松回归模型分析丹麦AMI住院情况随时间的变化。我们调查了七年期间:吸烟禁令实施前五年和实施后两年。我们考虑了人口规模的变化和季节性趋势。纳入的潜在混杂因素包括:性别、年龄和2型糖尿病(T2D)发病率。

结果

在对潜在混杂因素进行调整后,研究期间的最后三年AMI住院人数显著减少。在吸烟禁令实施前一年(相对率(RR)=0.86,95%置信区间(CI)0.79 - 0.94)、实施后一年(RR = 0.77,95%CI 0.71 - 0.85)和实施后两年(RR = 0.77,95%CI 0.70 - 0.84)均发现显著减少。

结论

在对T2D发病率进行调整后,在吸烟禁令实施前一年就已发现AMI住院人数显著减少。该结果与全球类似研究中的大多数结果不同,可能是由于丹麦逐步实施吸烟禁令以及2004年在全国范围内禁止食品中工业生产的反式脂肪酸所致。

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