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全州范围内禁烟令对急性心肌梗死发病率的影响。

The effect of a statewide smoking ordinance on acute myocardial infarction rates.

机构信息

Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colo.

Denver Health and the Rocky Mountain Poison and Drug Center, Denver, Colo.

出版信息

Am J Med. 2014 Jan;127(1):94.e1-6. doi: 10.1016/j.amjmed.2013.09.014. Epub 2013 Oct 1.

Abstract

BACKGROUND

Public smoking ordinances may reduce acute myocardial infarction events. Most studies assessed small communities with reported reductions as high as 40%. No reduction or smaller reductions were found in countrywide studies; less is known about the impact of statewide ordinances. We previously demonstrated identical 27% reductions in acute myocardial infarction hospitalizations in 2 Colorado communities after enactment of strict smoking ordinances. Subsequently, on July 1, 2006, a statewide ordinance went into effect. We sought to determine the impact of this legislation on acute myocardial infarction hospitalization rates.

METHODS

Hospital admissions for a primary acute myocardial infarction diagnosis were examined from 2000 to 2008. Poisson regression models were fit to the monthly events from January 1, 2000, to March 31, 2008. The final model included a quadratic trend over time, harmonic terms, and a post-ordinance effect. The model was adjusted temporally for population changes, using population estimates as an offset variable.

RESULTS

A total of 58,399 unique acute myocardial infarctions were recorded during the study period. No significant reduction in acute myocardial infarction rates was observed post-ordinance (relative risk, 1.059; 95% confidence interval, 0.993-1.131). However, a steep decline in acute myocardial infarction rates was noted from 2000 to 2005 just before enactment. There were 11 strict, local smoking ordinances in effect within Colorado before enactment of the statewide ordinance. After excluding these communities, the findings were similar (relative risk, 1.038; 95% confidence interval, 0.971-1.11).

CONCLUSIONS

Although local smoking ordinances in Colorado previously suggested a reduction in acute myocardial infarction hospitalizations, no significant impact of smoke-free legislation was demonstrated at the state level, even after accounting for preexisting ordinances.

摘要

背景

公共场所禁烟令可能会减少急性心肌梗死事件的发生。大多数研究评估的都是小社区,报告的减少率高达 40%。全国性研究则发现减少率没有那么高,甚至更小;关于全州禁烟令的影响则知之甚少。我们之前曾展示过,在科罗拉多州的两个社区颁布严格的禁烟令后,急性心肌梗死住院人数减少了 27%。随后,在 2006 年 7 月 1 日,全州禁烟令生效。我们试图确定该立法对急性心肌梗死住院率的影响。

方法

对 2000 年至 2008 年期间的原发性急性心肌梗死诊断住院患者进行了检查。使用泊松回归模型拟合 2000 年 1 月 1 日至 2008 年 3 月 31 日的每月事件。最终模型包括时间上的二次趋势、调和项和法令颁布后的影响。该模型在时间上根据人口变化进行了调整,使用人口估计数作为偏移变量。

结果

研究期间共记录了 58399 例独特的急性心肌梗死病例。在法令颁布后,急性心肌梗死率没有显著降低(相对风险,1.059;95%置信区间,0.993-1.131)。然而,在法令颁布前,2000 年至 2005 年期间,急性心肌梗死率急剧下降。在全州禁烟令颁布前,科罗拉多州已有 11 项严格的地方性禁烟令生效。在排除这些社区后,发现结果相似(相对风险,1.038;95%置信区间,0.971-1.11)。

结论

尽管科罗拉多州之前的地方性禁烟令表明急性心肌梗死住院人数有所减少,但即使考虑到先前存在的禁烟令,在州一级也没有发现无烟立法有显著影响。

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