前列腺素E1治疗阳痿，与罂粟碱的比较。

Prostaglandin E1 therapy for impotence, comparison with papaverine.

作者信息

Earle C M, Keogh E J, Wisniewski Z S, Tulloch A G, Lord D J, Watters G R, Glatthaar C

机构信息

Reproductive Medicine Research Institute, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia.

出版信息

J Urol. 1990 Jan;143(1):57-9. doi: 10.1016/s0022-5347(17)39864-6.

DOI:10.1016/s0022-5347(17)39864-6

PMID:2294263

Abstract

The efficacy of prostaglandin E1 as a pharmacological treatment of erectile dysfunction (impotence) was compared with the standard treatment, papaverine, in a single blind, crossover trial. A total of 129 impotent men received intracavernous injections of either prostaglandin E1 (5 micrograms) or papaverine (18 mg.) 1 month apart. Observations by 1 observer recorded 10 to 20 minutes after injection demonstrated that prostaglandin E1 generated a better erection in 72 men (55.8%) compared to papaverine. Papaverine was more effective than prostaglandin E1 in 23 men (17.8%, chi-square 6.26, p less than 0.025). Subjective assessment by the patients who detected a difference showed that 71 (55%) preferred prostaglandin E1 and 35 (27%) preferred papaverine (chi-square 11.56, p less than 0.001). A total of 34 men achieved full erections with prostaglandin E1 compared to 17 who used papaverine.

摘要

在一项单盲交叉试验中，将前列腺素E1作为勃起功能障碍（阳痿）的药物治疗效果与标准治疗药物罂粟碱进行了比较。共有129名阳痿男性接受了海绵体内注射，分别注射前列腺素E1（5微克）或罂粟碱（18毫克），间隔1个月。由1名观察者在注射后10至20分钟进行观察记录，结果显示，与罂粟碱相比，前列腺素E1使72名男性（55.8%）勃起情况更佳。罂粟碱在23名男性（17.8%）中比前列腺素E1更有效（卡方检验值6.26，p<0.025）。察觉到差异的患者进行主观评估，结果显示71名（55%）患者更喜欢前列腺素E1，35名（27%）患者更喜欢罂粟碱（卡方检验值11.56，p<0.001）。共有34名男性使用前列腺素E1后实现完全勃起，而使用罂粟碱的这一人数为17名。