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关注健康结局:重新审视白内障手术。

Focussing both eyes on health outcomes: revisiting cataract surgery.

机构信息

Centre for Clinical Epidemiology & Evaluation, Vancouver Coastal Health Research Institute, Vancouver, Canada.

出版信息

BMC Geriatr. 2012 Sep 3;12:50. doi: 10.1186/1471-2318-12-50.

Abstract

BACKGROUND

The appropriateness of cataract surgery procedures has been questioned, the suggestion being that the surgery is sometimes undertaken too early in the disease progression. Our three study questions were: What is the level of visual impairment in patients scheduled for cataract surgery? What is the improvement following surgery? Given the thresholds for a minimal detectable change (MDC) and a minimal clinically important difference (MCID), do gains in visual function reach the MDC and MCID thresholds?

METHODS

The sample included a prospective cohort of cataract surgery patients from four Fraser Health Authority ophthalmologists. Visual function (VF-14) was assessed pre-operatively and at seven weeks post-operatively. Two groups from this cohort were included in this analysis: 'all first eyes' (cataract extraction on first eye) and 'both eyes' (cataract removed from both eyes). Descriptive statistics, change scores for VF-14 for each eye group and proportion of patients who reach the MDC and MCID are reported.

RESULTS

One hundred and forty-two patients are included in the 'all first eyes' analyses and 55 in the 'both eyes' analyses. The mean pre-operative VF-14 score for the 'all first eyes' group was 86.7 (on a 0-100 scale where 100 is full visual function). The mean change in VF-14 for the 'both eyes' group was 7.5. Twenty-three percent of patients achieved improvements in visual function beyond the MCID threshold and 35% saw improvement beyond the MDC.

CONCLUSIONS

Neither threshold level for MDC or MCID for the VF-14 scale was achieved for a majority of patients. A plausible explanation for this is the very high levels of pre-operative visual functioning.

摘要

背景

白内障手术程序的适宜性受到了质疑,有人认为手术在疾病进展早期进行得过于频繁。我们的三个研究问题是:计划接受白内障手术的患者的视力障碍程度如何?手术后有何改善?鉴于最小可检测变化(MDC)和最小临床重要差异(MCID)的阈值,视力功能的提高是否达到 MDC 和 MCID 阈值?

方法

该样本包括来自弗雷泽卫生局四位眼科医生的白内障手术患者前瞻性队列。术前和术后七周评估视力功能(VF-14)。该队列中的两个小组被纳入本分析:“所有第一只眼”(第一只眼进行白内障摘除术)和“双眼”(双眼白内障切除)。报告了每个眼组的 VF-14 变化得分和达到 MDC 和 MCID 的患者比例的描述性统计数据。

结果

在“所有第一只眼”分析中纳入了 142 名患者,在“双眼”分析中纳入了 55 名患者。“所有第一只眼”组的术前平均 VF-14 评分为 86.7(0-100 分制,其中 100 分为完全视力)。“双眼”组的 VF-14 平均变化为 7.5。23%的患者视力功能改善超过 MCID 阈值,35%的患者改善超过 MDC。

结论

大多数患者均未达到 VF-14 量表的 MDC 或 MCID 阈值。对此的一个合理解释是术前视力水平非常高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b3e1/3497611/380ac2a79003/1471-2318-12-50-1.jpg

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