他达拉非和乙酰唑胺与乙酰唑胺预防严重高原病的比较。
Tadalafil and acetazolamide versus acetazolamide for the prevention of severe high-altitude illness.
机构信息
Center for Geographic Medicine and Internal Medicine C, Sheba Medical Center, Tel-Hashomer and Sackler Faculty of Medicine, Tel Aviv, Israel.
出版信息
J Travel Med. 2012 Sep-Oct;19(5):308-10. doi: 10.1111/j.1708-8305.2012.00636.x. Epub 2012 Jul 30.
Abstract
We report an open-label study comparing tadalafil and acetazolamide (n = 24) versus acetazolamide (n = 27) for prevention of high-altitude illness (HAI) at Mt. Kilimanjaro. Tadalafil group had lower rates of severe HAI compared with controls (4% vs 26%, p = 0.03), mostly because of decreased high-altitude pulmonary edema rates (4% vs 22%, p = 0.06).
摘要
我们报告了一项开放性研究，比较了他达拉非和乙酰唑胺（n=24）与乙酰唑胺（n=27）在预防乞力马扎罗山高原病（HAI）方面的效果。与对照组相比，他达拉非组严重 HAI 的发生率较低（4%比 26%，p=0.03），主要是因为高原肺水肿的发生率降低（4%比 22%，p=0.06）。
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