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鼻咽癌高发:婆罗洲的比达友族与中国南方百越族之间60%的线粒体DNA特征相似。

High incidence of nasopharyngeal cancer: similarity for 60% of mitochondrial DNA signatures between the Bidayuhs of Borneo and the Bai-yue of Southern China.

作者信息

Wee Joseph, Ha Tam Cam, Loong Susan, Qian Chao-Nan

出版信息

Chin J Cancer. 2012 Sep;31(9):455-6. doi: 10.5732/cjc.012.10192. Epub 2012 Aug 28.

DOI:10.5732/cjc.012.10192
PMID:22943598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3777505/
Abstract

Populations in Southern China (Bai-yue) and Borneo (Bidayuh) with high incidence of nasopharyngeal cancer(NPC) share similar mitochondrial DNA signatures, supporting the hypothesis that these two populations may share the same genetic predisposition for NPC, which may have first appeared in a common ancestral reference population before the sea levels rose after the last ice age.

摘要

中国南方(百越)和婆罗洲(比达友族)鼻咽癌(NPC)发病率高的人群具有相似的线粒体DNA特征,这支持了这样一种假设,即这两个人群可能对鼻咽癌具有相同的遗传易感性,这种易感性可能在末次冰期后海平面上升之前就已出现在一个共同的祖先参考人群中。

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本文引用的文献

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Evolutionary history of continental southeast Asians: "early train" hypothesis based on genetic analysis of mitochondrial and autosomal DNA data.大陆东南亚人的进化史:基于线粒体和常染色体 DNA 数据的遗传分析的“早期列车”假说。
Mol Biol Evol. 2012 Nov;29(11):3513-27. doi: 10.1093/molbev/mss169. Epub 2012 Jun 22.
2
The prevalence and prevention of nasopharyngeal carcinoma in China.中国鼻咽癌的患病率与预防
Chin J Cancer. 2011 Feb;30(2):114-9. doi: 10.5732/cjc.010.10377.
3
Ancient migration routes of Austronesian-speaking populations in oceanic Southeast Asia and Melanesia might mimic the spread of nasopharyngeal carcinoma.南岛语族人群在东南亚海洋地区和美拉尼西亚的古代迁徙路线可能与鼻咽癌的传播相似。
Chin J Cancer. 2011 Feb;30(2):96-105. doi: 10.5732/cjc.010.10589.
4
Nasopharyngeal carcinoma as a paradigm of cancer genetics.鼻咽癌作为癌症遗传学的一个范例。
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5
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.全基因组关联研究发现鼻咽癌三个新的易感性位点。
Nat Genet. 2010 Jul;42(7):599-603. doi: 10.1038/ng.601. Epub 2010 May 30.
6
Is nasopharyngeal cancer really a "Cantonese cancer"?鼻咽癌真的是“广东癌”吗?
Chin J Cancer. 2010 May;29(5):517-26. doi: 10.5732/cjc.009.10329.
7
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Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):482-6.
8
Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4.全基因组扫描家族性鼻咽癌揭示了与4号染色体连锁的证据。
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