口腔扁平苔藓患者全身用药的使用——与甲状腺功能减退症的可能关联。

Use of systemic medication in patients with oral lichen planus - a possible association with hypothyroidism.

作者信息

Robledo-Sierra J, Mattsson U, Jontell M

机构信息

Department of Oral Medicine and Pathology, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

出版信息

Oral Dis. 2013 Apr;19(3):313-9. doi: 10.1111/odi.12009. Epub 2012 Sep 3.

DOI:10.1111/odi.12009

PMID:22943671

Abstract

BACKGROUND

Several drugs have been regarded as a possible aetiological factor for oral lichen planus (OLP).

OBJECTIVE

To investigate the medication profile of patients with OLP and its possible association with the pathogenesis of OLP.

METHODS

Data from 956 patients with OLP and 1029 controls were collected using a standardized registration method. All regular medications were recorded and classified according to the Anatomical Therapeutic Chemical Classification System.

RESULTS

Patients with OLP used thyroid preparations (P < 0.001) and non-steroidal anti-inflammatory drugs (NSAIDs) (P < 0.01) in higher proportions compared to controls. A multivariate logistic regression model demonstrated that levothyroxine was associated with OLP (multivariate OR 3.39, 95% CI: 2.09-5.46, P < 0.001), even after controlling for confounders, including age, sex, smoking, allergies and systemic diseases. No statistical significance could be found between NSAIDs and OLP using the same model.

CONCLUSION

In this study, the use of levothyroxine was associated with OLP, which in turn suggests a possible connection with hypothyroidism.

摘要

背景

几种药物被认为可能是口腔扁平苔藓（OLP）的病因。

目的

调查OLP患者的用药情况及其与OLP发病机制的可能关联。

方法

采用标准化登记方法收集956例OLP患者和1029例对照的数据。记录所有常规用药，并根据解剖治疗化学分类系统进行分类。

结果

与对照组相比，OLP患者使用甲状腺制剂（P < 0.001）和非甾体抗炎药（NSAIDs）（P < 0.01）的比例更高。多因素逻辑回归模型显示，即使在控制了年龄、性别、吸烟、过敏和全身性疾病等混杂因素后，左甲状腺素仍与OLP相关（多因素OR 3.39，95%CI：2.09 - 5.46，P < 0.001）。使用同一模型未发现NSAIDs与OLP之间存在统计学意义。