维生素 D 在口腔扁平苔藓中的作用：一项病例对照研究。

Role of Vitamin D in Oral Lichen Planus: A Case Control Study.

机构信息

Department of Surgery and Medical-Surgical Specialties, Faculty of Medicine and Sciences of the Health, Oviedo University, 33006 Oviedo, Spain.

出版信息

Nutrients. 2024 Aug 19;16(16):2761. doi: 10.3390/nu16162761.

DOI:10.3390/nu16162761

PMID:39203896

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11357441/

Abstract

BACKGROUND

It has been reported that vitamin D deficiency may be associated with the development of oral lichen planus (OLP). Given the high prevalence of vitamin D deficiency in many countries, we sought to determine whether it constitutes a comorbidity of OLP.

METHODS

One hundred and twenty patients clinically and histologically diagnosed with OLP were evaluated for their serum vitamin D levels. The results were compared to results from a control series of the same number of subjects matched for age and sex.

RESULTS

Vitamin D deficiency was diagnosed in 45% ( = 54) of OLP patients and in 26.7% ( = 32) of the control group. Vitamin D supplements were being taken by 32 (26.7%) OLP patients and 15 (12.5%) subjects in the control group. A multivariate logistic regression model showed that OLP was associated with vitamin D deficiency [OR: 2.24 (1.28-3.98, = 0.005)] and vitamin D supplementation [OR: 2.51 (1.25-5.22, = 0.011)], even after controlling for confounding variables such as sex, age ≤60>, tobacco, and alcohol.

CONCLUSION

The association between OLP patients and vitamin D deficiency or vitamin D supplementation suggests that further research might explore the benefits of vitamin D supplements in managing OLP patients.

摘要

背景

已有报道称，维生素 D 缺乏可能与口腔扁平苔藓（OLP）的发生有关。鉴于许多国家维生素 D 缺乏的高发率，我们试图确定其是否构成 OLP 的合并症。

方法

对 120 例经临床和组织学诊断为 OLP 的患者进行血清维生素 D 水平评估。将结果与相同数量、年龄和性别匹配的对照组结果进行比较。

结果

45%（=54）的 OLP 患者和 26.7%（=32）的对照组被诊断为维生素 D 缺乏。32 例（26.7%）OLP 患者和 15 例（12.5%）对照组患者正在服用维生素 D 补充剂。多变量逻辑回归模型显示，OLP 与维生素 D 缺乏[比值比（OR）：2.24（1.28-3.98，=0.005）]和维生素 D 补充[OR：2.51（1.25-5.22，=0.011）]相关，即使在控制性别、年龄≤60 岁、吸烟和饮酒等混杂变量后也是如此。