膳食中二异壬基邻苯二甲酸酯（DINP）在妊娠和哺乳期给药对雄性大鼠性发育影响的剂量反应研究。
A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development.
机构信息
The Hamner Institutes for Health Sciences, Research Triangle Park, NC 27709, USA.
出版信息
Reprod Toxicol. 2013 Jan;35:70-80. doi: 10.1016/j.reprotox.2012.07.008. Epub 2012 Aug 18.
Male rat sexual development was evaluated after dietary administration of 0, 760, 3800, 11,400 ppm diisononyl phthalate (DiNP) and 7600 ppm dibutyl phthalate (DBP) from gestation day (GD) 12 to postnatal day (PND) 14. Maternal weight was reduced on GD 20, PND 2 and 14 at 11,400 ppm DiNP. Pup weight was reduced on PND 2 and 14 at 11,400 and 3800 ppm DiNP. DBP induced multinucleated germ cells (MNGs) and Leydig cell aggregates (LCAs) in PND 2 testes. 7600 ppm DBP reduced anogenital distance (AGD) on PND 2 and 14, and increased nipple retention and reproductive tract malformations on PND 49. DiNP induced MNGs (3800 ppm) and LCAs (11,400 ppm) on PND 2, and reduced AGD (11,400 ppm) on PND 14. DiNP did not alter AGD, nipple retention or reproductive tract malformations on PND 49. Global endpoint analysis showed no evidence of a rat "phthalate syndrome" on PND 49 with DiNP administration.
雄性大鼠的性发育在妊娠第 12 天到产后第 14 天经口给予 0、760、3800、11400ppm 邻苯二甲酸二异壬酯（DiNP）和 7600ppm 邻苯二甲酸二丁酯（DBP）后进行评估。在 11400ppm DiNP 时，母体体重在妊娠第 20 天、产后第 2 天和第 14 天减轻。在 11400 和 3800ppm DiNP 时，幼鼠体重在产后第 2 天和第 14 天减轻。DBP 在 PND 2 睾丸中诱导多核精原细胞（MNG）和间质细胞团（LCA）。7600ppm DBP 在 PND 2 和 14 时减少肛殖距（AGD），并在 PND 49 时增加乳头保留和生殖道畸形。DiNP 在 PND 2 时诱导 MNG（3800ppm）和 LCA（11400ppm），并在 PND 14 时减少 AGD（11400ppm）。DiNP 在 PND 49 时不会改变 AGD、乳头保留或生殖道畸形。总终点分析显示，在 PND 49 时给予 DiNP 没有大鼠“邻苯二甲酸酯综合征”的证据。
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