Zhang Yong-ming, Lin Jiang-tao
China-Japan Friendship Hospital, Beijing, China.
Zhonghua Yi Xue Za Zhi. 2012 Jul 24;92(28):1971-3.
To evaluate the normal values of fractional exhaled nitric oxide (FENO) for Chinese adults.
A total of 200 non-smoking and healthy Chinese adults were recruited according to the inclusion and exclusion criteria. They received lung function and allergen skin prick tests at the Outpatient Department of China-Japan Friendship Hospital from February to August 2011. There were 100 males and 100 females. FENO test was performed according to the standard procedures of American Thoracic Society/European Respiratory Society (ATS/ERS) recommendation. The FENO levels of healthy non-smokers were tested by the NIOXMINO analyzer. All variables, such as age, gender, height, weight, forced expiratory volume at 1 second (FEV(1))% predicted and FEV(1)/FVC, were included for multiple regression analyses.
The FENO level of healthy non-smokers was (14.2 ± 5.6)×10(-9) mol/L with the 95% normal range of (3.2 - 25.2)×10(-9) mol/L. The value of FENO was significantly higher in males than females ((15.6 ± 5.5) vs (12.9 ± 5.4)×10(-9) mol/L, t = 3.48, P = 0.001). The FENO level of the subjects aged 60 - 80 years was (15.7 ± 5.4)×10(-9) mol/L and it was higher than those aged 18 - 60 years ((13.8 ± 5.6)×10(-9) mol/L, t = 2.04, P = 0.040). Multiple regression analysis showed that gender was an independent influencing factor of FENO level.
The FENO level of non-smoking and healthy Chinese adults is similar with that of the westerners. Gender is an independent influencing factor of FENO level.
评估中国成年人呼出气一氧化氮分数（FENO）的正常值。
根据纳入和排除标准，共招募了200名不吸烟的健康中国成年人。他们于2011年2月至8月在中国-日本友好医院门诊部接受了肺功能和过敏原皮肤点刺试验。其中男性100名，女性100名。FENO检测按照美国胸科学会/欧洲呼吸学会（ATS/ERS）推荐的标准程序进行。使用NIOX MINO分析仪检测健康非吸烟者的FENO水平。纳入所有变量，如年龄、性别、身高、体重、第1秒用力呼气量（FEV(1)）占预计值百分比和FEV(1)/FVC，进行多元回归分析。
健康非吸烟者的FENO水平为（14.2±5.6）×10⁻⁹mol/L，95%正常范围为（3.2 - 25.2）×10⁻⁹mol/L。男性的FENO值显著高于女性（（15.6±5.5）对（12.9±5.4）×10⁻⁹mol/L，t = 3.48，P = 0.001）。60 - 80岁受试者的FENO水平为（15.7±5.4）×10⁻⁹mol/L，高于18 - 60岁者（（13.8±5.6）×10⁻⁹mol/L，t = 2.04，P = 0.040）。多元回归分析显示，性别是FENO水平的独立影响因素。
不吸烟的健康中国成年人的FENO水平与西方人相似。性别是FENO水平的独立影响因素。
