基质金属蛋白酶-7（MMP-7）和第10号染色体缺失的磷酸酶及张力蛋白同源物（PTEN）在结直肠癌中的表达的临床意义

Clinical significance of MMP-7 and PTEN expression in colorectal cancer.

作者信息

Bi Zheng, Dong Lai-Dong, Gu Xiao-Meng

机构信息

Department of Clinical Laboratory, Qilu Hospital of Shandong University, Shandong Province, China.

出版信息

Hepatogastroenterology. 2013 Jan-Feb;60(121):32-6. doi: 10.5754/hge12537.

DOI:10.5754/hge12537

PMID:22944341

Abstract

BACKGROUND/AIMS: The aim of this study was to investigate the expression of MMP-7 and PTEN protein in colorectal cancer and explore its correlation with clinicopathological parameters.

METHODOLOGY

In colorectal cancer tissue samples (n=48) and normal rectal tissue samples (n=23), the expression of MMP-7 and PTEN was detected by immunohistochemistry. Using medical records, the relationship of MMP-7 and PTEN expression with clinicopathological parameters was analyzed.

RESULTS

Compared to normal rectal tissue, MMP-7 expression was significantly higher in all grades of colorectal cancer. In contrast, PTEN expression was significantly lower than levels in normal rectal tissue. There was significant negative correlation between MMP-7 and PTEN expression in colorectal cancer (r=-0.403, p>0.05). MMP-7 and PTEN expression in colorectal cancer samples was correlated with differentiation, lymph node metastasis, serosa infiltration, and Duke's stage (p<0.05) but not with gender, age, or tumor size (p>0.05).

CONCLUSIONS

Reduced PTEN expression and MMP-7 over-expression may play important roles in the pathogenesis of colorectal cancer. Combined detection may provide prognostic benefit towards colorectal cancer.

摘要

背景/目的：本研究旨在调查基质金属蛋白酶-7（MMP-7）和第10号染色体缺失的磷酸酶和张力蛋白同源物（PTEN）蛋白在结直肠癌中的表达情况，并探讨其与临床病理参数的相关性。

方法

采用免疫组织化学方法检测48例结直肠癌组织样本和23例正常直肠组织样本中MMP-7和PTEN的表达。利用病历资料分析MMP-7和PTEN表达与临床病理参数的关系。

结果

与正常直肠组织相比，各级结直肠癌组织中MMP-7表达均显著升高。相反，PTEN表达显著低于正常直肠组织水平。结直肠癌中MMP-7与PTEN表达呈显著负相关（r=-0.403，p>0.05）。结直肠癌样本中MMP-7和PTEN表达与分化程度、淋巴结转移、浆膜浸润及杜克分期相关（p<0.05），但与性别、年龄或肿瘤大小无关（p>0.05）。