Li Boyou, Cao Feilin, Zhu Qinlu, Li Boli, Gan Meifu, Wang Dongguo
Medical School of Taizhou College, Taizhou, Zhejiang Province, China.
Hepatogastroenterology. 2013 Mar-Apr;60(122):244-7. doi: 10.5754/hge12573.
BACKGROUND/AIMS: Cimetidine has been shown to play an important role in the treatment of cancer and the regulation of the immune system. Therefore, we aimed to observe the effects of cimetidine on the systematic immune response in the perioperative period.
Sixty patients with colorectal cancer were enrolled from Jan 2005 to Dec 2005 from Taizhou Hospital. The patients were administrated with cimetidine (0.8 g.d-1 or 1.2 g.d-1) or saline from the day of admission to the 10th POD. Venous blood sample was collected and the T-, B- and NK-lymphocyte subsets were determined by flow cytometry. The specimens were subjected to tumor-infiltrating lymphocytes (TILs) response examination.
The levels of CD3 and CD4 T-lymphocytes were increased significantly in both low and high dose cimetidine groups 10 days after operation. The number of CD19 B cells was also elevated by cimetidine. However, no significant changes were observed in the CD8, CD4/CD8 value. TIL responses in the cimetidine groups were also enhanced significantly.
Cimetidine can alleviate systematic immunosuppression and improve the local immune function of the colorectal cancer patients in the perioperative period.
背景/目的：已证明西咪替丁在癌症治疗和免疫系统调节中发挥重要作用。因此，我们旨在观察西咪替丁在围手术期对全身免疫反应的影响。
2005年1月至2005年12月从台州医院招募了60例结直肠癌患者。患者从入院当天至术后第10天接受西咪替丁（0.8 g·d⁻¹或1.2 g·d⁻¹）或生理盐水治疗。采集静脉血样本，通过流式细胞术测定T、B和NK淋巴细胞亚群。对标本进行肿瘤浸润淋巴细胞（TILs）反应检测。
术后10天，低剂量和高剂量西咪替丁组的CD3和CD4 T淋巴细胞水平均显著升高。西咪替丁还使CD19 B细胞数量增加。然而，CD8、CD4/CD8值未观察到显著变化。西咪替丁组的TIL反应也显著增强。
西咪替丁可减轻结直肠癌患者围手术期的全身免疫抑制，改善局部免疫功能。
