Kiedrowski Miroslaw, Mroz Andrzej
Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences - SGGW, Warsaw, Poland ; Department of Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Department of Gastroenterology and Hepatology, Medical Centre for Postgraduate Education, Warsaw, Poland.
Contemp Oncol (Pozn). 2014;18(4):222-6. doi: 10.5114/wo.2014.44296. Epub 2014 Aug 20.
Like many malignancies, the development of colorectal carcinoma (CRC) can be considered as an imbalance between the compromised process of programmed cell death (apoptosis) and excessive, uncontrolled proliferation. Several mutations and epigenetic alterations are acquired during colorectal carcinogenesis. These are responsible for the cell cycle regulation, cellular sensitivity to pro- and antiapoptotic factors, cell proliferation, angiogenesis, invasiveness, as well as metastatic potential. The molecular alterations, along with their morphological expressions, have been recognised in detail, and most of the CRC cases can be attributed to either adenoma-carcinoma or serrated neoplasia pathways: in the first, the antiapoptotic features prevail; while in the second, the proliferative activity is of the utmost importance. The aim of the work is to discuss the influence of selected drugs and dietary compounds on the proliferation and apoptosis in CRC.
与许多恶性肿瘤一样，结直肠癌（CRC）的发生可被视为程序性细胞死亡（凋亡）受损过程与过度、不受控制的增殖之间的失衡。在结直肠癌发生过程中会出现多种突变和表观遗传改变。这些改变负责细胞周期调控、细胞对促凋亡和抗凋亡因子的敏感性、细胞增殖、血管生成、侵袭性以及转移潜能。分子改变及其形态学表现已得到详细认识，并且大多数结直肠癌病例可归因于腺瘤 - 癌或锯齿状肿瘤形成途径：在第一种途径中，抗凋亡特征占主导；而在第二种途径中，增殖活性至关重要。这项工作的目的是讨论所选药物和膳食化合物对结直肠癌增殖和凋亡的影响。
