Clendenon N R, Barth R F, Gordon W A, Goodman J H, Alam F, Staubus A E, Boesel C P, Yates A J, Moeschberger M L, Fairchild R G
Department of Neurology, Ohio State University, Columbus.
Neurosurgery. 1990 Jan;26(1):47-55. doi: 10.1097/00006123-199001000-00007.
The purpose of the present study was to utilize a well-established rat glioma to evaluate boron neutron capture therapy for the treatment of malignant brain tumors. Boron-10 (10B) is a stable isotope which, when irradiated with thermal neutrons, produces a capture reaction yielding high linear energy transfer particles (10B + 1nth----[11B]----4He(alpha) + 7Li + 2.79 MeV). The F98 tumor is an anaplastic glioma of CD Fischer rat origin with an aggressive biological behavior similar to that of human glioblastoma multiforme. F98 cells were implanted intracerebrally into the caudate nuclei of Fischer rats. Seven to 12 days later the boron-10-enriched polyhedral borane, Na2B12H11SH, was administered intravenously at a dose of 50 mg/kg body weight at varying time intervals ranging from 3 to 23.5 hours before neutron irradiation. Pharmacokinetic studies revealed blood 10B values ranging from 0.33 to 10.5 micrograms/ml depending upon the time after administration, a T1/2 of 6.2 hours, normal brain 10B concentrations of 0.5 microgram/g, and tumor values ranging from 1.1 to 12.8 micrograms/g. No therapeutic gain was seen if the capture agent was given at 3 or 6 hours before irradiation with 4 x 10(12) n/cm2 (10 MW-min; 429 cGy). A 13.5-hour preirradiation interval resulted in a mean survival of 37.8 days (P less than 0.01), compared to 30.5 days (P less than 0.03) for irradiated controls and 22.1 days for untreated animals.(ABSTRACT TRUNCATED AT 250 WORDS)
本研究的目的是利用一种成熟的大鼠胶质瘤模型来评估硼中子俘获疗法对恶性脑肿瘤的治疗效果。硼-10（¹⁰B）是一种稳定同位素，当用热中子辐照时，会发生俘获反应，产生高线性能量传递粒子（¹⁰B + ¹nth→[¹¹B]→⁴He（α粒子） + ⁷Li + 2.79兆电子伏特）。F98肿瘤是源自CD Fischer大鼠的间变性胶质瘤，其侵袭性生物学行为与人类多形性胶质母细胞瘤相似。将F98细胞脑内植入Fischer大鼠的尾状核。7至12天后，在中子辐照前3至23.5小时的不同时间间隔，静脉注射剂量为50毫克/千克体重的富含硼-10的多面体硼烷Na₂B₁₂H₁₁SH。药代动力学研究表明，根据给药后的时间不同，血液中¹⁰B值在0.33至10.5微克/毫升之间，半衰期为6.2小时，正常脑组织中¹⁰B浓度为0.5微克/克，肿瘤中¹⁰B值在1.1至12.8微克/克之间。如果在以4×10¹² n/cm²（10兆瓦-分钟；429厘戈瑞）进行辐照前3或6小时给予俘获剂，则未观察到治疗增益。辐照前间隔13.5小时导致平均生存期为37.8天（P＜0.01），相比之下，辐照对照组为30.5天（P＜0.03），未治疗动物为22.1天。（摘要截短于250字）
