School of Clinical Medicine University of Cambridge, Cambridge, UK.
Psychiatr Danub. 2012 Sep;24 Suppl 1:S117-8.
The Kraepelinian dichotomy sees schizophrenia and bipolar disorder as two distinctly separate diseases each with its own pathogenesis and disease process. This study looks at the difference between patients with schizophrenia and bipolar disorder in terms of suicidal behaviour. Both schizophrenia and bipolar disorder have been identified as significant risk factors for suicide, while bipolar and major depressive disorder appear to be the greatest diagnostic indicators. This study also aims to look at any differences in suicidal behaviour between the two major classes of bipolar disorder (bipolar I and bipolar II) to possibly determine how distinct these two conditions are in this respect. As expected, this study found that patients with a diagnosis of bipolar disorder were significantly more likely (OR=4.79) to have a history of suicidal behaviour than patients with a diagnosis of schizophrenia. Neither bipolar I nor bipolar II patients were significantly more likely to have a history of suicidal behaviour. However, this study yielded a weak association between bipolar II patients and suicidal behaviour (OR=1.83) compared to bipolar I patients, which may have been more significant under different circumstances such as a greater sample size.
克氏分裂症将精神分裂症和双相情感障碍视为两种截然不同的疾病，每种疾病都有其自身的发病机制和病程。本研究着眼于精神分裂症和双相情感障碍患者在自杀行为方面的差异。精神分裂症和双相情感障碍都已被确定为自杀的重要危险因素，而双相情感障碍和重度抑郁症似乎是最大的诊断指标。本研究还旨在观察两种主要类型的双相情感障碍（I 型和 II 型）之间自杀行为的任何差异，以确定这两种疾病在这方面的区别程度。不出所料，本研究发现，被诊断为双相情感障碍的患者（OR=4.79）比被诊断为精神分裂症的患者更有可能有自杀行为史。I 型或 II 型双相情感障碍患者均无明显更有可能有自杀行为史。然而，与 I 型双相情感障碍患者相比，本研究发现 II 型双相情感障碍患者与自杀行为之间存在较弱的关联（OR=1.83），这种关联在其他情况下可能更为显著，例如样本量更大。
