South Essex Partnership University Foundation Trust, Bedford, UK.
Psychiatr Danub. 2012 Sep;24 Suppl 1:S197-201.
We assess the number of patients who we have on the Database of a Community Mental Health Team in the UK who have Bipolar Disorder and Borderline Personality Disorder. We report how many of these have been seen as having both disorders. Hence we discuss the issue as to whether Borderline Personality disorder is to be placed within the bipolar spectrum. We note the difficulties regarding the use of phenomenology alone to decide this problem, and we note the similarities in genetics, neuroimaging observations and neurobiological mechanisms among the following conditions; Bipolar Disorder, Unipolar Depression, Post-traumatic Stress Disorder, and Borderline Personality Disorder. Ethiologies such as Trauma, Abuse, Childhood adversity and exposure to War appear to influence all these conditions via epigenetic mechanisms. Hence we argue that for a spectrum to be proposed, conditions in the spectrum need to be underpinned by similar or common Neuroimaging and neurobiological mechanisms.On this basis, it may be reasonable to include Borderline Personality Disorder within a broadly described bipolar spectrum. New details of the common Neurobiological mechanisms continue to emerge.
我们评估了英国社区心理健康团队数据库中患有双相情感障碍和边缘型人格障碍的患者数量。我们报告了其中有多少人同时患有这两种疾病。因此，我们讨论了边缘型人格障碍是否应归入双相情感障碍谱系的问题。我们注意到仅使用现象学来解决这个问题存在困难，并且我们注意到以下情况在遗传学、神经影像学观察和神经生物学机制方面存在相似之处：双相情感障碍、单相抑郁、创伤后应激障碍和边缘型人格障碍。创伤、虐待、童年逆境和战争暴露等病因似乎通过表观遗传机制影响所有这些疾病。因此，我们认为，为了提出一个谱系，该谱系中的疾病需要有相似或共同的神经影像学和神经生物学机制作为支撑。在此基础上，将边缘型人格障碍纳入广义描述的双相情感障碍谱系中是合理的。共同神经生物学机制的新细节不断涌现。
