The First Affiliated Hospital of Liaoning Medical University, Jinzhou 121001, Liaoning, China.
Appl Biochem Biotechnol. 2012 Oct;168(4):910-6. doi: 10.1007/s12010-012-9829-y. Epub 2012 Sep 4.
Ovarian cancer lacks clear syndromes at an early stage and could result in serious problem in woman's health status. The current diagnostic approach relies on physical examination, ultrasound examination, and blood test for CA125. These approaches could not diagnose early stage ovarian cancer with high sensitivity and specificity. The present paper reviewed the efforts in screening the proteomic biomarkers for ovarian cancer. The sources of biomarkers were discussed. Then, the current techniques in proteomics were introduced. Finally, the biomarkers for ovarian cancer were summarized.
卵巢癌在早期缺乏明显的症状，可能会对女性的健康状况造成严重影响。目前的诊断方法依赖于体格检查、超声检查和 CA125 血液检测。这些方法不能以高灵敏度和特异性诊断早期卵巢癌。本文综述了筛选卵巢癌蛋白质组生物标志物的研究进展。讨论了生物标志物的来源。然后介绍了蛋白质组学的当前技术。最后总结了卵巢癌的生物标志物。
