用于口腔外远处肿瘤的唾液癌生物标志物

Rapado-González Óscar, Majem Blanca, Muinelo-Romay Laura, López-López Rafa, Suarez-Cunqueiro María Mercedes

Department of Surgery and Surgical Medical Specialties, Medicine and Dentistry School, University of Santiago de Compostela, Santiago de Compostela 15782, Spain.

Biomedical Research Unit in Gynecology, Vall Hebron Research Institute (VHIR) and University Hospital, Autonomous University of Barcelona, Barcelona 08035, Spain.

Int J Mol Sci. 2016 Sep 12;17(9):1531. doi: 10.3390/ijms17091531.

The analysis of saliva as a diagnostic approach for systemic diseases was proposed just two decades ago, but recently great interest in the field has emerged because of its revolutionary potential as a liquid biopsy and its usefulness as a non-invasive sampling method. Multiple molecules isolated in saliva have been proposed as cancer biomarkers for diagnosis, prognosis, drug monitoring and pharmacogenetic studies. In this review, we focus on the current status of the salivary diagnostic biomarkers for different cancers distant to the oral cavity, noting their potential use in the clinic and their applicability in personalising cancer therapies.

仅仅在二十年前，唾液分析作为一种用于系统性疾病的诊断方法才被提出，但近来该领域受到了极大关注，这是因为其作为液体活检具有革命性潜力，且作为一种非侵入性采样方法十分有用。唾液中分离出的多种分子已被提议作为癌症生物标志物用于诊断、预后、药物监测和药物遗传学研究。在这篇综述中，我们聚焦于口腔外不同癌症的唾液诊断生物标志物的现状，指出它们在临床中的潜在用途以及在癌症个性化治疗中的适用性。