Photobiology Unit, Dermatology Centre, Inflammation Sciences Research Group, School of Translational Medicine, University of Manchester, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Hospital, Manchester M6 8HD, UK.
Photochem Photobiol Sci. 2013 Jan;12(1):29-36. doi: 10.1039/c2pp25158b.
This article reviews recent data on the expression, regulation and activation of antimicrobial peptides (AMP) in human skin, and considers their potential protective and pro-inflammatory roles following upregulation by ultraviolet radiation (UVR). Antimicrobial peptides are small peptides that are key components of the innate immune system, originally identified by their vital role in protecting the body-environment interface from infection. However, it has now become clear that AMP have more extensive actions, including the provision of pivotal links with the adaptive immune system. Moreover, aberrant AMP expression may contribute to immuno-modulated inflammatory dermatoses including psoriasis, eczema and the photoaggravated condition lupus erythematosus. Recent work has demonstrated the direct upregulation of AMP in healthy skin by cutaneous UVR exposure. This may serve to protect the skin from risks imposed by both the biophysical barrier-compromise and the immunosuppression that are attributable to UVR exposure. Furthermore, it is observed that UVR provokes upregulation of AMP in an atypical manner in the photosensitivity disorder polymorphic light eruption. Dysregulated UVR responses of these pro-inflammatory proteins may play a role in the pathogenesis of certain immune-mediated diseases caused or aggravated by sunlight.
本文综述了人皮肤中抗菌肽（AMP）的表达、调节和激活的最新数据，并考虑了它们在紫外线辐射（UVR）上调后的潜在保护和促炎作用。抗菌肽是小肽，是先天免疫系统的关键组成部分，最初因其在保护身体-环境界面免受感染方面的重要作用而被识别。然而，现在已经很清楚，AMP 具有更广泛的作用，包括与适应性免疫系统提供关键联系。此外，异常的 AMP 表达可能导致免疫调节性炎症性皮肤病，包括银屑病、湿疹和光加重性狼疮。最近的研究表明，皮肤 UVR 暴露可直接上调健康皮肤中的 AMP。这可能有助于保护皮肤免受 UVR 暴露引起的生物物理屏障破坏和免疫抑制的风险。此外，还观察到在光敏感障碍多形性光疹中，UVR 以非典型方式引发 AMP 的上调。这些促炎蛋白的失调 UVR 反应可能在某些由阳光引起或加重的免疫介导性疾病的发病机制中发挥作用。
