Kareus Seth A, Figueroa Karla P, Cannon-Albright Lisa A, Pulst Stefan M
Arch Neurol. 2012 Dec;69(12):1572-7. doi: 10.1001/archneurol.2012.2261.
OBJECTIVE To use a statewide population-based genealogic database to evaluate the relationship between Parkinson disease (PD) and cancer subtypes. DESIGN Using a computerized genealogy for the Utah pioneers and their descendants linked to a statewide cancer registry and statewide death certificates, we estimated relative risks for cancer in individuals with PD listed on their death certificate, and in their first-degree, second-degree, and third-degree relatives. SETTING Utah Cancer Registry. PARTICIPANTS Approximately 2.3 million individuals in the Utah genealogic resource, including death certificates of 2998 individuals with PD listed as a cause of death from 1904 to 2008 and information on 100 817 individuals with a cancer diagnosis in the Utah Cancer Registry. RESULTS Melanoma and prostate cancer were the only cancers observed in significant excess among PD cases; colorectal, lung, pancreas, and stomach cancers were observed in deficit. A significantly increased risk for prostate cancer was observed in the PD population as well as among their relatives. A reciprocal significantly increased risk for PD was also found in the 22 147 prostate cancer cases and their relatives. A significantly elevated risk for melanoma was found in the Utah PD population as well as in their relatives. A reciprocal significantly increased relative risk for PD was found in 7841 Utah melanoma cases and their relatives. CONCLUSIONS Our study identified a novel association between PD and prostate cancer, which extended to first-degree, second-degree, and third-degree relatives. We also confirmed the reported risk association for melanoma in patients with PD; we extended the finding to include a significantly increased risk in relatives. These results strongly support a genetic link. This conclusion is further strengthened by observation of the reciprocal relationship, an increased risk for PD in relatives of individuals with melanoma or prostate cancer.
目的 利用一个基于全州人口的系谱数据库评估帕金森病（PD）与癌症亚型之间的关系。设计 利用犹他州先驱者及其后代的计算机化系谱，这些系谱与全州癌症登记处和全州死亡证明相链接，我们估计了死亡证明上列出患有PD的个体及其一级、二级和三级亲属患癌症的相对风险。地点 犹他州癌症登记处。参与者 犹他州系谱资源中的约230万人，包括1904年至2008年列为死因的2998例PD患者的死亡证明，以及犹他州癌症登记处中100817例癌症诊断患者的信息。结果 黑色素瘤和前列腺癌是仅在PD病例中显著超量观察到的癌症；结直肠癌、肺癌、胰腺癌和胃癌观察到不足。在PD人群及其亲属中观察到前列腺癌风险显著增加。在22147例前列腺癌病例及其亲属中也发现了PD的反向显著增加风险。在犹他州PD人群及其亲属中发现黑色素瘤风险显著升高。在7841例犹他州黑色素瘤病例及其亲属中发现了PD的反向显著增加相对风险。结论 我们的研究确定了PD与前列腺癌之间的一种新关联，这种关联扩展到一级、二级和三级亲属。我们还证实了报道的PD患者中黑色素瘤的风险关联；我们将这一发现扩展到包括亲属中显著增加的风险。这些结果有力地支持了遗传联系。黑色素瘤或前列腺癌患者亲属中PD风险增加的反向关系的观察进一步加强了这一结论。
