Azizi Esther, Feuerman Hana, Peleg Idit, Pavlotsky Felix, Segal Zvi, Oberman Bernice, Lev Nirit, Hodak Emmilia, Djaldetti Ruth, Hassin-Baer Sharon, Inzelberg Rivka
Department of Dermatology Chaim Sheba Medical Center Tel Hashomer Israel.
Faculty of Medicine & Health Sciences Tel Aviv University Tel Aviv Israel.
Skin Health Dis. 2024 Oct 4;4(6):e464. doi: 10.1002/ski2.464. eCollection 2024 Dec.
An epidemiological link between Parkinson's disease (PD) and cutaneous malignant melanoma (CMM) has been widely reported. The role of CMM risk factors in this association is unclear.
To compare rates of risk factors for skin tumours, specifically actinic keratosis (AK), non-melanoma skin cancer (NMSC) and CMM, between persons with and without PD.
In this cross-sectional observational study, patients attending tertiary PD clinics and community controls were interviewed for background/medical data and underwent dermatological examination. Logistic regression models assessed risk factors for skin tumours and their interactions with PD status.
Included were 141 persons with PD and 155 controls; mean age 71.7 and 72.6 years, respectively. In both groups, the majority were males of Ashkenazi origin. Altogether, AK, basal cell carcinoma, squamous cell carcinoma and CMM were recorded in 76 (53.9%) persons with PD and 92 (59.3%) controls (NS). CMM prevalence predominated in PD patients. In the PD group, prolonged sun exposure ( = 0.007), freckles ( < 0.001) and solar lentigines ( = 0.008) were associated with skin tumours. In the control group, dysplastic atypical moles were negatively associated with skin tumours ( = 0.017). Logistic regression of the whole cohort showed that older age ( < 0.001), fair complexion ( = 0.04) and prolonged sun exposure ( = 0.01) were associated with skin tumours, but PD status was not independently associated, and no interactions were found between PD status and CMM risk factors.
Periodic dermatological screening of PD populations is mandatory, especially for carriers of major phenotypic risk factors or presenting with AK, NMSC or CMM.
帕金森病（PD）与皮肤恶性黑色素瘤（CMM）之间的流行病学关联已被广泛报道。CMM危险因素在这种关联中的作用尚不清楚。
比较PD患者与非PD患者皮肤肿瘤危险因素的发生率，特别是光化性角化病（AK）、非黑色素瘤皮肤癌（NMSC）和CMM。
在这项横断面观察性研究中，对三级PD诊所的患者和社区对照者进行背景/医学数据访谈，并进行皮肤科检查。逻辑回归模型评估皮肤肿瘤的危险因素及其与PD状态的相互作用。
纳入141例PD患者和155例对照者；平均年龄分别为71.7岁和72.6岁。两组中，大多数为阿什肯纳兹血统的男性。PD患者和对照者中，共有76例（53.9%）和92例（59.3%）记录有AK、基底细胞癌、鳞状细胞癌和CMM（无统计学差异）。CMM患病率在PD患者中占主导。在PD组中，长时间日晒（P = 0.007）、雀斑（P < 0.001）和日光性黑子（P = 0.008）与皮肤肿瘤相关。在对照组中，发育异常的非典型痣与皮肤肿瘤呈负相关（P = 0.017）。整个队列的逻辑回归显示，年龄较大（P < 0.001）、肤色白皙（P = 0.04）和长时间日晒（P = 0.01）与皮肤肿瘤相关，但PD状态并非独立相关，且未发现PD状态与CMM危险因素之间存在相互作用。
对PD人群进行定期皮肤科筛查是必要的，特别是对于主要表型危险因素携带者或患有AK、NMSC或CMM的患者。
